Mayo Clinic Laboratory and pathology research roundup: May 23

By Samantha Rossi • May 23, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era.

How to identify follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. Building on a prior study demonstrating the early transformation of FLs with high variant allele frequency (VAF) BCL2 mutations at activation-induced cytidine deaminase (AICDA) sites, we examined 11 AICDA mutational targets, including BCL2, BCL6, PAX5, PIM1, RHOH, SOCS, and MYC, in 199 newly diagnosed grade 1 and 2 FLs. BCL2 mutations with VAF ≥20% occurred in 52% of cases.

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Published to PubMed This Week

• Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients.
  PLoS One
• The landscape of parasitic infections in the United States.
  Modern Pathology
• Perioperative management of vitamin K antagonists and direct oral anticoagulants: A systematic review and meta-analysis.
  Chest
• "A monument to suffering and to patience": The harrowing journey of Nabby Adams through breast cancer.
  Journal of Medical Biography
• EZH2 and POU2F3 can aid in the distinction of thymic carcinoma from thymoma.
  Cancers (Basel)
• The good, the bad, and the ugly: Operative staff perspectives of surgeon coping with intraoperative errors.
  Surgery
• Cutibacterium acnes in spine tissue: Characteristics and outcomes of non-hardware-associated vertebral osteomyelitis.
  Journal of bone and joint infection
• Troponin T levels and when to peek using CMR in patients with MINOCA.
  Canadian Journal of Cardiology
• Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era.
  Blood Cancer Journal
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.