Mayo Clinic Laboratory and pathology research roundup: June 27

By Samantha Rossi • June 27, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

SARS-CoV-2 spike codon mutations and risk of hospitalization after antispike monoclonal antibody therapy in solid organ transplant recipients.

Neutralizing antispike monoclonal antibody (mAb) therapies were highly efficacious in preventing coronavirus disease 2019 (COVID-19) hospitalization. While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may harbor spike protein mutations conferring reduced in vitro susceptibility to these antibodies, the effect of these mutations on clinical outcomes is not well characterized. We conducted a case-control study of solid organ transplant recipients who received an antispike mAb for treatment of mild-to-moderate COVID-19 and had an available sample from initial COVID-19 diagnosis for genotypic sequencing.

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Published to PubMed This Week

• Digital hepatic iron content: An artificial intelligence model for spatially-resolved histologic iron quantitative analysis in liver samples.
  Lab investigation
• Evaluation of the analytical sensitivity of ACON and LumiraDx SARS-CoV-2 rapid antigen tests using samples with presumed Omicron variant.
  Diagnostic microbiology and Infectious Diseases
• Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation.
  Clinical and translation medicine
• Incidence of metformin use in patients with age-related macular degeneration versus normal controls: A population-based study in Olmsted County, Minnesota.
  Eye (London)
• The impact of metastasis histopathology on oncologic outcomes for patients with surgically resected metastatic renal cell carcinoma.
  Journal of Urology
• Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation.
  Clinical and translation medicine
• Patient satisfaction with a multi-site, multi-regional remote patient monitoring program for acute and chronic condition management: A survey-based descriptive snalysis.
  Journal of medical internet research
• Comparison of clinical, genetic, and pathologic features of limbic and diffuse transactive response DNA-binding protein 43 pathology in alzheimer's disease neuropathologic spectrum.
  Journal of Alzheimer's Disease
• A Radiologist's guide to the 2021 WHO Central Nervous System Tumor Classification: Part 2-newly described and revised tumor types.
  Radiology
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.