Mayo Clinic Laboratory and pathology research roundup: July 4

By Samantha Rossi • July 4, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Emergence of inducible macrolide resistance in mycobacterium chelonae due to broad-host-range plasmid and chromosomal variants of the novel 23S rRNA methylase gene, erm(55).

Macrolides are a mainstay of therapy for infections due to nontuberculous mycobacteria (NTM). Among rapidly growing mycobacteria (RGM), inducible macrolide resistance is associated with four chromosomal 23S rRNA methylase (erm) genes. Beginning in 2018, we detected high-level inducible clarithromycin resistance (MICs of ≥16μg/mL) in clinical isolates of Mycobacterium chelonae, an RGM species not previously known to contain erm genes. Using whole-genome sequencing, we identified a novel plasmid-mediated erm gene.

Read more.

Published to PubMed This Week

• Single troponin measurement to rule out myocardial infarction: JACC review topic of the week.
  Journal of the American College of Cardiology
• Diagnosis and prognosis of type 2 myocardial infarction using objective evidence of acute myocardial ischemia: A validation study.
  American Journal of Medicine
• Visualization of preretinal membranes using trypan blue in patients with traction retinal detachments.
  Canadian journal of ophthalmology
• Outcomes of transplant recipients with pretransplant Nocardia colonization or infection.
  Transplants infectious disease
• New diagnostics for the spectrum of asymptomatic TB: From infection to subclinical disease.
  International journal of tuberculosis and lung disease
• Validation of molecular International Prognostic Scoring System (IPSS-M) in myelodysplastic/myeloproliferative neoplasms, not otherwise specified (MDS/MPN-NOS).
  Leukemia research
• An effective combination therapy for the treatment of pediatric monomorphic post-transplant lymphoproliferative disorder with plasmacytic differentiation.
  Journal of pediatric hematology and oncology
• Clinical validation of tagmentation-based genome sequencing for germline disorders.
  Journal of Molecular Diagnostics
• Rhabdomyosarcoma arising in inflammatory rhabdomyoblastic tumor: A genetically distinctive subtype of rhabdomyosarcoma.
  Modern Pathology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.