Mayo Clinic Laboratory and pathology research roundup: July 11

By Samantha Rossi • July 11, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Comparison of two assays to diagnose herpes simplex virus in patients with central nervous system infections.

Multiplex PCR panels are frequently used for detecting the diagnosis of central nervous system infection, but have demonstrated lower sensitivity for herpes simplex virus (HSV) compared to targeted PCRs. Providers in our institution frequently order both multiplex (BioFire Meningitis/Encephalitis Panel (MEP)) and targeted HSV PCR (Diasorin Simplexa HSV-1/2 Direct), allowing comparison of assay performance in practice and a unique clinical characterization of patients with concordant positive or discordant results.

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Published to PubMed This Week

• Establishing NK-cell receptor restriction by flow cytometry and detecting potential NK-cell clones of uncertain significance.
  Modern Pathology
• Single troponin measurement to rule out myocardial infarction: JACC review topic of the week.
  Journal of the American College of Cardiology
• Artificial intelligence-based reticulin proportionate area - a novel histological outcome predictor in hepatocellular carcinoma.
  Histopathology
• Open-spaced ridged hydrogel scaffolds containing TiO₂-self-assembled monolayer of phosphonates promote regeneration and recovery following spinal cord injury.
  International Journal of Molecular Science
• Do quantitative levels of antispike-IgG antibodies aid in predicting protection from SARS-CoV-2 infection? Results from a longitudinal study in a police cohort.
  Journal of Medical Virology
• Molecular and immunophenotypic correlates of metastatic epithelioid angiomyolipoma include alterations of TP53, RB1, and ATRX.
  Archives of Pathology and Laboratory Medicine
• Clinical characteristics of central nervous system phaeohyphomycosis: A brief report of 20 years' experience.
  Medical Mycology
• Characteristics of aortic and pulmonary valve cusp fenestrations in healthy hearts.
  Cardiovascular Pathology
• Gastrointestinal amyloidosis: An often unexpected finding with systemic implications.
  Human Pathology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.