Mayo Clinic Laboratory and pathology research roundup: July 18

By Samantha Rossi • July 18, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Natural history, predictors of development of extramedullary disease, and treatment outcomes for patients with extramedullary multiple myeloma.

Extramedullary multiple myeloma (EMM) can present either at initial diagnosis (de novo) or at disease relapse (secondary) and confers an aggressive clinical course. Limited data exist for choosing the optimal therapy for EMM and this remains an area of unmet clinical need. After excluding paraskeletal multiple myeloma and primary plasma cell leukemia, we identified 204 (68%) patients with secondary EMM and 95 (32%) with de novo EMM between January 01, 2000 and 31 December, 2021.

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Published to PubMed This Week

• Circulating antigen-primed cytotoxic T-cells in patients with renal tumors treated with surgery.
  Urologic Oncology
• Troponin T levels and when to peek ssing CMR in patients with MINOCA.
  The Canadian Journal of Cardiology
• Expanded extracorporeal membrane oxygenation bridge to heart and lung transplant candidate selection does not impact outcomes compared to traditional candidate selection criteria.
  Journal of Thoracic Disease
• Schistosomiasis of the urinary bladder.
  Mayo Clinic Proceedings
• Osteoid osteomas of the hands and feet: A series of 71 cases.
  Virchows Archiv: An international journal of pathology
• Analytic result variation for high-sensitivity cardiac troponin: Interpretation and consequences.
  The Canadian Journal of Cardiology
• Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study.
  Bone Marrow Transplant
• Fusion-driven spindle cell rhabdomyosarcomas of bone and soft tissue: A clinicopathologic and molecular genetic study of 25 cases.
  Modern Pathology
• Somatic TP53 single nucleotide variants, indels and copy number alterations in chronic myelomonocytic leukemia (CMML).
  Leukemia
• Tubular and glomerular size by cortex depth as predictors of progressive chronic kidney disease after radical nephrectomy for tumor.
  Journal of American Society of Nephrology
• Histopathology of meningiomas.
  Advances in experimental medicine and biology
• Outcomes of critically ill older adults with COVID-19: A multicentre retrospective cohort study.
  Canadian Journal of Anesthesiology
• 16S rRNA gene PCR/sequencing of heart valves for diagnosis of infective endocarditis in routine clinical practice.
  Journal of Clinical Microbiology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.