Mayo Clinic Laboratory and pathology research roundup: July 25

By Samantha Rossi • July 25, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

The clinical and molecular spectrum of ETV6 mutated myeloid neoplasms.

ETV6 mutations are rare but recurrent somatic events in myeloid neoplasms and are negatively prognostic in myelodysplastic syndrome. We set out to examine the clinical and molecular characteristics of patients undergoing investigation for myeloid neoplasms, found to have deleterious ETV6 mutations. ETV6 mutations occurred in 33 of 5793 (0.6%) cases investigated and predominantly in high-risk disease entities including MDS with increased blasts, primary myelofibrosis and AML, myelodysplasia-related. 

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Published to PubMed This Week

• Mechanomyography as a surgical adjunct for treatment of chronic entrapment neuropathy: A case series.
  Operative Neurosurgery
• Systematic review of procedural skill simulation in health care in low- and middle-income countries.
  Simulation in healthcare
• Histopathology of meningiomas.
  Advances in experimental medicine and biology
• Glioneuronal and neuronal tumors of the central nervous system.
  Advances in experimental medicine and biology
• A second case of liraglutide-type localised amyloidosis.
  Amyloid
• Changes in renal-mesenteric duplex ultrasound velocities after fenestrated and branched endovascular aortic aneurysm repair.
  Journal of vascular surgery
• Platelet genetic testing by next-generation sequencing: A practical update.
  International journal of laboratory hematology
• Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria.
  Annals of clinical and translational neurology
• Novel NONO::TFE3 fusion and ALK co-expression identified in a subset of cutaneous microcystic/reticular schwannoma.
  Virchows Archiv

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.