Mayo Clinic Laboratory and pathology research roundup: August 1

By Samantha Rossi • August 1, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

A lncRNA from the FTO locus acts as a suppressor of the m⁶A writer complex and p53 tumor suppression signaling.

N⁶-methyladenosine (m⁶A) of mRNAs modulated by the METTL3-METTL14-WTAP-RBM15 methyltransferase complex and m⁶A demethylases such as FTO play important roles in regulating mRNA stability, splicing, and translation. Here, we demonstrate that FTO-IT1 long noncoding RNA (lncRNA) was upregulated and positively correlated with poor survival of patients with wild-type p53-expressing prostate cancer (PCa). m⁶A RIP-seq analysis revealed that FTO-IT1 knockout increased mRNA m⁶A methylation of a subset of p53 transcriptional target genes (e.g., FAS, TP53INP1, and SESN2) and induced PCa cell cycle arrest and apoptosis. 

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Published to PubMed This Week

• Performance of an artificial intelligence model for recognition and quantitation of histologic features of eosinophilic esophagitis on biopsy samples.
  Modern Pathology
• Sodium-glucose co-transporter-2 inhibitor therapy and unmasking of JAK2-mutated myeloproliferative neoplasm: A Mayo Clinic series of nine consecutive cases.
  American Journal of Hematology
• Extraenteric malignant gastrointestinal neuroectodermal tumor-a clinicopathologic and molecular genetic study of 11 cases.
  Modern Pathology
• Comparative gene expression profiling reveals differential expression of GATA3 and Wnt signaling in juxtaglomerular cell tumors compared to renal glomus tumors.
  Human Pathology
• Emergence of inducible macrolide resistance in mycobacterium chelonae due to broad-host-range plasmid and chromosomal variants of the novel 23S rRNA methylase gene, erm(55).
  Journal of Clinical Microbiology
• Anakinra-associated systemic amyloidosis.
  Arthritis and Rheumatology
• Feasibility of probe washing after stereotactic needle biopsy as a novel technique for developing cell lines and xenografts of H3 K27-altered diffuse midline gliomas.
  Journal of Neurosurgery. Pediatrics
• Retrospective single-surgeon study of prone versus lateral robotic pedicle screw placement: a CT-based assessment of accuracy.
  Journal of Neurosurgery. Spine
• Impact of cytogenetic abnormalities on the risk of disease progression in solitary bone plasmacytomas.
  Blood
• Germline mutations in 12 genes and risk of ovarian cancer in three population-based cohorts.
  Cancer Epidemiology, Biomarkers and Prevention

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.