Mayo Clinic Laboratory and pathology research roundup: August 8

By Samantha Rossi • August 8, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Age-based versus young-adult thresholds for nephrosclerosis on kidney biopsy and prognostic implications for CKD.

Nephrosclerosis (glomerulosclerosis, interstitial fibrosis, and tubular atrophy) is the defining pathology of both kidney aging and CKD. Optimal thresholds for nephrosclerosis that identify persons with a progressive disease are unknown. This study determined a young-age threshold (18-29 years) and age-based 95th percentile thresholds for nephrosclerosis on the basis of morphometry of kidney biopsy sections from normotensive living kidney donors. These thresholds were 7.1-fold to 36-fold higher in older (70 years or older) versus younger (aged 18-29 years) normotensive donors. Age-based thresholds, but not young-age threshold, were prognostic for determining risk of progressive CKD among patients who underwent a radical nephrectomy or a for-cause native kidney biopsy, suggesting that age-based thresholds are more useful than a single young-age threshold for identifying CKD on biopsy.

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Published to PubMed This Week

• Unpacking the CNS manifestations of Epstein-Barr Virus: An imaging perspective.
  AJNR. American Journal of Neuroradiology
• MDM2 amplification status in a cohort of well-characterized myxofibrosarcoma: A clinicopathologic analysis of 22 tumors.
  International Journal of Surgical Pathology
• Patient satisfaction with a multisite, multiregional remote patient monitoring program for acute and chronic condition management: Survey-based analysis.
  Journal of Medicine and Internet Research
• Antineutrophil cytoplasmic antibody-associated vasculitis and VEXAS syndrome: Comment on the article by Muratore et al.
  Arthritis and Rheumatology
• Outcomes of infliximab-treated inflammatory bowel disease patients undergoing therapeutic drug monitoring with two different assays.
  Clinical Biochemistry
• Validation of molecular international prognostic scoring system (IPSS-M) in myelodysplastic/myeloproliferative neoplasms, not otherwise specified (MDS/MPN-NOS).
  Leukemia Research
• MICon contamination detection workflow for next-generation sequencing laboratories using microhaplotype loci and supervised learning.
  Journal of Molecular Diagnostics
• GFR estimated with creatinine rather than cystatin C is more reflective of the true risk of adverse outcomes with low GFR in kidney transplant recipients.
  Nephrology, Dialysis, Transplantation
• The evolving role of cardiac troponin: From acute to chronic coronary syndromes.
  Journal of American College of Cardiology
• Functional and clinical characterization of variants of uncertain significance identifies a hotspot for inactivating missense variants in RAD51C.
  Cancer Research

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.