Test for LDL subtype helps manage coronary risk
Answers from the Lab
Small dense LDL cholesterol (sdLDL-c) is an important biomarker for understanding a patient's risk of coronary heart disease. In this test-specific episode of the "Answers From the Lab" podcast, Vlad Vasile, M.D., Ph.D., and Leslie Donato, Ph.D., explain how Mayo Clinic Laboratories' assay measuring sdLDL-c concentrations aids clinical management of patients with high LDL or "bad" cholesterol.
"sdLDL-c is a particular type of harmful cholesterol that is thought to be highly atherogenic," Dr. Vasile says. "Patients with elevated LDL cholesterol might or might not have high small dense LDL. The sdLDL-c assay identifies the category of patients at higher risk, who might otherwise be missed in clinical practice."
The results can directly impact clinical care.
"The higher the cholesterol concentration in these small dense particles, the higher the risk of future cardiovascular events," Dr. Donato says. "sdLDL-c test results can help guide decisions about initiating or intensifying a pharmacotherapy, to lower overall atherosclerotic cardiovascular disease risk."
Listen to learn more about Mayo Clinic Laboratories' sdLDL-c assay.
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Aiding in risk management of lipoprotein disorders associated with cardiovascular disease when used in conjunction with other lipid measurements and clinical evaluation.
Patient Preparation: Fasting: Overnight (8-12 hours)
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Patients with elevated LDL or "bad" cholesterol face even greater risk if their levels of small dense LDL cholesterol are also high. Vlad Vasile, M.D., Ph.D., and Leslie Donato, Ph.D., explain how Mayo Clinic Laboratories' sdLDL-c assay measures concentrations of the small dense LDL subtype, to better guide clinical care.
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