Mayo Clinic Laboratory and pathology research roundup: August 15

By Samantha Rossi • August 15, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.

Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient specimens and this co-occurrence accelerates prostatic oncogenesis. p53 gain-of-function (GOF) mutants are now shown to bind to a unique DNA sequence in the CTNNB1 gene promoter and transactivate its expression. 

Read more.

Published to PubMed This Week

• The evolving role of cardiac troponin: From acute to chronic coronary syndromes.
  Journal of the American College of Cardiology
• Gynecologic-type adenocarcinoma with mixed serous and endometrioid features in a male patient.
  Mayo Clinic Proceedings
• Benign enhancing foramen magnum lesions.
  AJNR American Journal of Neuroradiology
• Candida guilliermondii/Kodamaea ohmeri endocarditis.
  Mycopathologia
• Association of adverse effects with high serum posaconazole concentrations.
  Medical Mycology
• Somatic TP53 single nucleotide variants, indels and copy number alterations in chronic myelomonocytic leukemia (CMML).
  Leukemia
• Relationship among three common hematological premalignant conditions.
  Leukemia
• Two tumors with combined features of bronchiolar adenoma/ciliated muconodular papillary tumor and sclerosing pneumocytoma.
  American Journal of Clinical Pathology
• Update on endoscopic dysplasia surveillance in IBD.
  American Journal of Gastroenterology
• A lncRNA from the FTO locus acts as a suppressor of the m⁶A writer complex and p53 tumor suppression signaling.
  Molecular Cell

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.