Mayo Clinic Laboratory and pathology research roundup: September 5

By Samantha Rossi • September 5, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

16S rRNA gene PCR/Sequencing of heart valves for diagnosis of infective endocarditis in routine clinical practice.

Sequencing is increasingly used for infective endocarditis (IE) diagnosis. Here, the performance of 16S rRNA gene PCR/sequencing of heart valves utilized in routine clinical practice was compared with conventional IE diagnostics. Subjects whose heart valves were sent to the clinical microbiology laboratory for 16S rRNA gene PCR/sequencing from August 2020 through February 2022 were studied. A PCR assay targeting V1 to V3 regions of the 16S rRNA gene was performed, followed by Sanger and/or next-generation sequencing (NGS) (using an Illumina MiSeq), or reported as negative, depending on an algorithm that included the PCR cycle threshold value.

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Published to PubMed This Week

• Follicular lymphoma and diffuse large c-cell lymphoma with BCL2 and IRF4 rearrangements in adult patients.
  Human Pathology
• Anaplastic large cell lymphomas with equivocal DUSP22 FISH results: recommendations for clinical reporting and diagnostic evaluation.
  Human Pathology
• Mohs surgery for female genital Paget's disease: A prospective observational trial.
  American Journal of Obstetrics Gynecology
• Antifungal susceptibility pattern of Candida glabrata from a referral center and reference laboratory: 2012-2022.
  Journal of Fungi (Basel)
• Projection of realistic three-dimensional photogrammetry models using stereoscopic display: A technical note.
  Anatomical Science Education

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.