Anti-Platelet Factor 4 Antibody-Mediated Prothrombotic Syndromes

Video Length: 48 minutes


In this month's "Virtual Lecture," Anand Padmanabhan, M.B.B.S., Ph.D., associate professor of laboratory medicine and pathology at Mayo Clinic, provides a general overview and science in the field related to heparin-induced thrombocytopenia (HIT), vaccine-induced thrombotic thrombocytopenia (VITT), and monoclonal gammopathy of thrombotic significance (MGTS). The lecture also focuses on impacts related to diagnosis for anti-platelet factor 4-mediated thrombotic syndromes.


Photo of Anand Padmanabhan, M.B.B.S., Ph.D.

Anand Padmanabhan, M.B.B.S., Ph.D.

Associate Professor of Laboratory Medicine and Pathology
Division of Hematopathology
Mayo Clinic, Rochester, Minnesota

Learning objectives

Upon completion of this activity, participants should be able to:

  • Recall that platelet factor 4 (PF4) is a target of antibodies in certain prothrombotic states.
  • Review the heterogeneity of presentations in anti-PF4 mediated syndromes. 
  • Discuss the pathophysiology of a recently recognized anti-PF4 mediated prothrombotic disease, monoclonal gammopathy of thrombotic significance (MGTS).

Intended audience

This program is appropriate for clinicians, pathologists, medical technologists, nurses, pharmacists, and other allied health staff.


The following types of credit are offered for this event:


Mayo Clinic Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® program. This program has been approved for a maximum of 1.0 P.A.C.E.® contact hour.

State of Florida

Mayo Clinic Laboratories is approved as a Continuing Education Accrediting Agency for the Clinical Laboratory Sciences for the State of Florida. Florida Board of Clinical Laboratory Personnel has designated this program for General (Hematology) credit. This program has been approved for 1.0 contact hour.

To obtain credit

1. Watch the video.

2. Complete the post-test and evaluation that launches immediately following the video.

3. Generate and print your certificate(s).

Level of instruction for this program is intermediate.

Credit expires 9/27/2025

Faculty disclosure

Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty members also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentations. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentations.


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This post was developed by our Education and Technical Publications Team.