Mayo Clinic Laboratory and pathology research roundup: October 3

By Sarah Jarvis • October 3, 2023

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.

Gene fusions involving tumor protein p63 gene (TP63) occur in multiple T and B cell lymphomas and portend a dismal prognosis for patients. The function and mechanisms of TP63 fusions remain unclear, and there is no target therapy for patients with lymphoma harboring TP63 fusions. Here, we show that TP63 fusions act as bona fide oncogenes and are essential for fusion-positive lymphomas.

Read more.

Published to PubMed This Week

• Mycobacterium abscessus subspecies identification using the Deeplex Myc-TB targeted NGS assay.
  Journal of Clinical Microbiology
• EWSR1::POU2AF3(COLCA2) sarcoma: An aggressive, polyphenotypic sarcoma with a head and neck predilection
  Modern Pathology
• Benefits and challenges of remote patient monitoring as perceived by health care practitioners: A systematic review.
  The Permanente Journal
• Machine learning algorithms predict long-term postoperative opioid misuse: A systematic review.
  The American Surgeon
• Digital hepatic iron content: An artificial intelligence model for spatially resolved histologic iron quantitative analysis in liver samples.
  Lab Investigation
• Mast cell cytomorphology and treatment outcome in mast cell leukemia.
  American Journal of Hematology
• Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative phosphaturic mesenchymal tumors of bone and sinonasal tract.
  Modern Pathology
• Primary and specialist palliative care in neurosurgery: A narrative review and bibliometric analysis of glioblastoma and stroke.
  World Neurosurgery
• A new test method for biochemical analysis of plasmalogens in dried blood spots and erythrocytes from patients with peroxisomal disorders.
  Journal of Inherited Metabolic Disease
• Artificial elevation of phosphatidylethanol due to red blood cell transfusion.
  Clinical Biochemistry
• From patterns to proteins: Mass spectrometry comes of age in glomerular disease.
  Journal of the American Society of Nephrology
• The impact of teleneonatology on the Transport Risk Index of Physiologic Stability score for outborn neonates: A prospective, observational study.
  Journal of Telemedicine and Telecare
• Use of next-generation sequencing to detect mutations associated with antiviral drug resistance in cytomegalovirus.
  Journal of Clinical Microbiology
• The immunome of mobilized peripheral blood stem cells is predictive of long-term outcomes and therapy-related myeloid neoplasms in patients with multiple myeloma undergoing autologous stem cell transplant.
  Blood Cancer Journal
• Frontotemporal hypometabolism in medication-induced tardive dyskinesia.
  Neurology
• Ability for fine needle aspiration and frozen section to predict extent of parotidectomy.
  Head & Neck
• Poor sensitivity of the MALDI Biotyper^® MBT subtyping module for detection of Klebsiella pneumoniae Carbapenemase (KPC) in Klebsiella species.
  Antibiotics
• Fatal infections differentially involve allograft and native lungs in single lung transplant recipients.
  Archives of Pathology and Laboratory Medicine

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.