Mayo Clinic Laboratory and Pathology Research Roundup: October 17

By Sarah Jarvis • October 17, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Synthesizing images of tau pathology from cross-modal neuroimaging using deep learning.

Given the prevalence of dementia and the development of pathology-specific disease modifying therapies, high-value biomarker strategies to inform medical decision making are critical. In-vivo tau positron emission tomography (PET) is an ideal target as a biomarker for Alzheimer's disease diagnosis and treatment outcome measure. However, tau PET is not currently widely accessible to patients compared to other neuroimaging methods. In this study, we present a convolutional neural network (CNN) model that impute tau PET images from more widely-available cross-modality imaging inputs. Participants (n=1,192) with brain T1-weighted MRI (T1w), fluorodeoxyglucose (FDG) PET, amyloid PET, and tau PET were included. 

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Published to PubMed This Week

• Fever, cough, and pancytopenia in a transplant recipient.
  Clinical Infectious Diseases
• An autobiographical case report on papillary thyroid carcinoma with positive antithyroid antibodies: Coincidence or correlated?
  Cureus
• Molecular alterations in primary and metastatic PEComa: Insights from the AACR project GENIE dataset.
  Human Pathology
• Clinical utility of a cytomegalovirus-specific T cell assay in assessing the risk of post-prophylaxis cytomegalovirus infection and post-treatment relapse.
  Clinical Transplantation
• Long term outcomes in patients with anti-DPPX autoimmunity.
  Journal of Neuroimmunology
• Incorrect laboratory test selection is common in the evaluation of alpha-gal syndrome and Fabry disease.
  Journal of Allergy and Clinical Immunology
• Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification.
  Mayo Clinic Proceedings
• Primary and secondary diagnoses in medicine: Insights from Mayo Clinic consensus report on membranous nephropathy--Executive summary.
  Mayo Clinic Proceedings
• Molecular classification and identification of an aggressive signature in low-grade B-cell lymphomas.
  Hematological Oncology
• Treatment intensification might not improve survival in high-grade B-cell lymphoma with a concurrent MYC and BCL2 and/or BCL6 rearrangement: A retrospective, multicenter, pooled analysis.
  Hematological Oncology
• Using an anomaly detection approach for the segmentation of colorectal cancer tumors in whole slide images.
  Journal of Pathology Informatics
• CRP versus SAA for identification of inflammatory hepatic adenomas.
  Applied Immunochemistry & Molecular Morphology
• Identification of SARS-CoV-2 from human lung formalin-fixed paraffin-embedded tissue sections using mass spectrometry.
  OMICS

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.