Mayo Clinic Laboratory and Pathology Research Roundup: December 12

By Sarah Jarvis • December 12, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Impact of cytogenetic abnormalities on the risk of disease progression in solitary bone plasmacytomas.

Most patients with solitary bone plasmacytomas (SBP) progress to multiple myeloma (MM) after definitive radiation therapy as their primary treatment. Whether the presence of high-risk (HR) cytogenetic abnormalities by fluorescence in situ hybridization (FISH) in the clonal plasma cells, obtained either directly from the diagnostic SBP tissue or the corresponding bone marrow examination at the time of diagnosis, is associated with a shorter time to progression (TTP) to MM is unknown. This study evaluated all patients diagnosed with SBP at the Mayo Clinic from January 2012 to July 2022.

Read more.

Published to PubMed This Week

• Analysis of hypoglycemic drugs by liquid chromatography-tandem mass spectrometry.
  Methods in Molecular Biology
• Emergence of TP53 mutation during lenalidomide therapy of myelodysplastic syndrome with del(5q) and its subsequent disappearance following salvage therapy with decitabine.
  Haematologica
• Candida guilliermondii/Kodamaea ohmeri Endocarditis.
  Mycopathologia
• Clinical specificity of two assays for immunoglobulin kappa and lambda free light chains.
  Clinical Chemistry and Laboratory Medicine
• Sarcomas harboring EWSR1::PATZ1 fusions: A clinicopathologic study of 17 cases.
  Modern Pathology
• Metastatic lung adenocarcinoma presenting as hydrocele.
  Mayo Clinic Proceedings
• Benefit of anticoagulation early after surgical aortic valve replacement using bioprosthetic valves.
  Mayo Clinic Proceedings
• Endoscopic submucosal dissection with versus without traction for pathologically staged T1B esophageal cancer: A multicenter retrospective study.
  Gastrointestinal Endoscopy
• Liver mass as first-time diagnosis of sarcomatoid anaplastic thyroid carcinoma: A rare malignancy presenting at an unexpected nody site.
  The American Journal of Case Reports
• Impact of pancreas transplantation alone on kidney function: A multicenter clinical cohort study.
  Clinical Transplantation
• Two tumors with combined features of bronchiolar adenoma/ciliated muconodular papillary tumor and sclerosing pneumocytoma.
  American Journal of Clinical Pathology
• Lack of observed interference by therapeutic monoclonal antibodies in select commonly utilized immunoassays.
  Clinical Biochemistry
• Targeted testing of bone marrow specimens with cytoplasmic vacuolization to identify previously undiagnosed cases of VEXAS syndrome.
  Rheumatology
• Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis.
  Cell Death & Disease
• Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia.
  JCI Insight
• Hereditary gelsolin amyloidosis: a rare cause of cranial, peripheral and autonomic neuropathies linked to D187N and Y447H substitutions.
  Amyloid
• The effect of plasma exchange on serum levels of lacosamide: A case report.
  American Journal of Health System Pharmacy
• Smartphone sensor data estimate alcohol craving in a cohort of patients with alcohol-associated liver disease and alcohol use disorder.
  Hepatology Communications
• Identification of amyloidosis of the urinary tract and prostate: Opportunities for early diagnosis & intervention in systemic disease.
  Human Pathology
• Assessment of PD-L1, TROP2, and nectin-4 expression in penile squamous cell carcinoma.
  Human Pathology
• Benign female genital tract smooth muscle tumors with adipocytic differentiation: A  morphologic, immunohistochemical and MDM2 fluorescence in situ hybridization study of 44 conventional lipoleiomyomas and lipoleiomyoma variants.
  Human Pathology
• Myxofibrosarcoma in adolescents and young adults: a clinicopathologic study of 17 cases.
  Human Pathology
• Advanced systemic mastocytosis-Revised classification, new drugs and how we treat.
  British Journal of Haematology

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.