Mayo Clinic Laboratory and Pathology Research Roundup: January 2

By Sarah Jarvis • January 2, 2024

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Sarcoma: An aggressive, polyphenotypic sarcoma with a head and neck predilection.

EWSR1::POU2AF3 (COLCA2) sarcomas are a recently identified group of undifferentiated round/spindle cell neoplasms with a predilection for the head and neck region. Herein, we report our experience with 8 cases, occurring in 5 men and 3 women (age range, 37-74 years; median, 60 years). Tumors involved the head/neck (4 cases), and one each the thigh, thoracic wall, fibula, and lung. Seven patients received multimodal therapy; 1 patient was treated only with surgery. Clinical follow-up (8 patients; range, 4-122 months; median, 32 months) showed 5 patients with metastases (often multifocal, with a latency ranging from 7 to 119 months), and 3 of them also with local recurrence.

Read more.

Published to PubMed This Week

• Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative phosphaturic mesenchymal tumors of bone and sinonasal tract.
  Modern Pathology
• CT findings in idiopathic myointimal hyperplasia of mesenteric veins (IMHMV) and comparison to other colitides.
  Abdominal Radiology
• Malignant glomus tumor arising in association with a fumarate hydratase-deficient leiomyoma: An unusual collision tumor.
  Journal of Cutaneous Pathology
• Resection of a solitary right ventricular metastasis in oligorecurrent hepatocellular carcinoma.
  Journal of Clinical Medicine
• Peri-procedural myocardial infarction/injury after percutaneous coronary intervention.
  European Heart Journal
• Diffuse hemispheric glioma with H3-3B G34R mutation: Expanding the spectrum of histone H3 genes in diffuse hemispheric glioma, H3 G34-mutant.
  Journal of Neuropathology and Experimental Neurology
• Multiparametric flow cytometry in the evaluation of plasma cell proliferative disorders: Current paradigms for clinical practice.
  Clinical Lymphoma, Myeloma & Leukemia
• Timing and morbidity of intracranial meningioma resection complications.
  World Neurosurgery
• Prospective evaluation of upper extremity access and total transfemoral approach during fenestrated and branched endovascular repair.
  Journal of Vascular Surgery
• Clinicopathologic features of a novel star-shaped transactive response DNA-binding protein 43 (TDP-43) pathology in the oldest old.
  Journal of Neuropathology and Experimental Neurology
• Next generation sequencing-based identification of fusion-driven renal neoplasia: A single institution experience.
  Human Pathology
• Metastatic clear cell papillary renal cell 'tumour'.
  Histopathology
• Germline genetic testing for hereditary breast and ovarian cancer: Current concepts in risk evaluation.
  Cold Spring Harbor Perspectives in Medicine

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.