Mayo Clinic Laboratory and Pathology Research Roundup: January 30

By Sarah Jarvis • January 30, 2024

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Interleukin-21 drives a hypermetabolic state and CD4⁺ T cell-associated pathogenicity in chronic intestinal inflammation.

Incapacitated regulatory T cells (Tregs) contribute to immune-mediated diseases. Inflammatory Tregs are evident during human inflammatory bowel disease (IBD); however, mechanisms driving the development of these cells and their function are not well understood. Therefore, we investigated the role of cellular metabolism in Tregs relevant to gut homeostasis.

Read more.

Published to PubMed This Week

• Lophomonas as a respiratory pathogen-jumping the gun.
  Journal of Clinical Microbiology
• One thousand patients with essential thrombocythemia: the Mayo Clinic experience.
  Blood Cancer Journal
• Computational flow cytometry accurately identifies sezary cells based on simplified aberrancy and clonality features.
  The Journal of Investigative Dermatology
• Circulating immunophenotypes are potentially prognostic in follicular cell-derived thyroid cancer.
  Frontiers in Immunology
• Mimickers of immunoglobulin G4-related hepatobiliary disease on biopsy.
  Seminars in Diagnostic Pathology
• Peripheral nervous system manifestations of MOG antibody associated disease.
  Annals of Clinical and Translational Neurology
• Extent of surgical resection as a predictor of tumor progression in skull base Cchordomas: A multicenter volumetric analysis.
  World Neurosurgery
• IgG4-related kidney disease: Clinicopathologic features, differential diagnosis, and mimics.
  Seminars in Diagnostic Pathology
• COVID-19 infection and risk stratification for pulmonary embolism: Identifying optimal D-dimer thresholds.
  Thrombosis Research
• von Hippel-Lindau disease-related neoplasia with an emphasis on renal manifestations.
  Seminars in Diagnostic Pathology
• An evaluation of untargeted metabolomics methods to characterize inborn errors of metabolism.
  Molecular Genetics and Metabolism
• Thyroid gland blastomycosis.
  Endocrine Pathology
• Monoclonal immunoglobulin crystalline membranous Nnephropathy.
  American Journal of Kidney Diseases
• Multimodal imaging findings associated with cardiac oxalosis cardiomyopathy.
  JACC
• Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia.
  JCI Insight
• Comparison of plasma biomarkers and amyloid PET for predicting memory decline in cognitively unimpaired individuals.
  Alzheimers & Dementia

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.