Assay enhances and simplifies M-proteins screening

Answers from the Lab

In this test-specific episode of the "Answers From the Lab" podcast, David Murray, M.D., Ph.D., explains how Mayo Clinic Laboratories' new MASS-FIX Quantitation assay offers higher specificity for quantitating m-proteins in the blood, which are associated with multiple myeloma and other diseases. The new MASS-FIX Quantitative assay further enhances the MASS-FIX mass spectrometry method developed at Mayo Clinic, of which greatly improved screening for M-proteins.

The new assay (test code: QMPSS) provides greater specificity and the ease of ordering the right test at the right time for patients, for diagnostic or monitoring purposes.

"With Quantitative MASS-FIX, we're now able to achieve a significantly more specific level of quantitation than we had for SPEP," Dr. Murray says. "This new method is going to replace the traditional SPEP and immunofixation, so only one test will need to be ordered."

The new assay, QMPSS, is the fruit of five years of laboratory work, including building unique software to perform the quantitation. "Our new assay brings in more sensitivity and specificity. This is going to change the way patients are treated," Dr. Murray says.

Listen to learn more about Mayo Clinic Laboratories' MASS-FIX Quantitation assay.

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Barbara J. Toman

Barbara J. Toman is a Senior Communications Specialist at Mayo Clinic Laboratories. She is also the science writer for Mayo’s Neurosciences Update newsletter, which helps referring physicians to stay informed about Mayo’s treatment and research. Barbara has worked at Mayo Clinic since 2007. She enjoys international travel and cooking.