Mayo Clinic Laboratory and Pathology Research Roundup: March 12

By Sarah Jarvis • March 12, 2024

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy.

C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), both of which are characterized by bright glomerular C3 staining on immunofluorescence studies. However, on electron microscopy (EM), DDD is characterized by dense osmiophilic mesangial and intramembranous deposits along the glomerular basement membranes (GBM), while the deposits of C3GN are not dense. Why the deposits appear dense in DDD and not in C3GN is not known. We performed laser microdissection (LCM) of glomeruli followed by mass spectrometry (MS) in 12 cases each of DDD, C3GN, and pretransplant kidney control biopsies.

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Published to PubMed This Week

• In reply to serum free light chain and drift: Calibrator adjustment needed?
  The Journal of Applied Laboratory Medicine
• Membranous nephropathy treatment standard.
  Nephrology, Dialysis, Transplantation
• Multiparametric flow cytometry in the evaluation of plasma cell proliferative disorders: Current paradigms for clinical practice.
  Clinical Lymphoma, Myeloma, and Leukemia
• Primary multiglandular parathyroid disease in the setting of Pompe Disease.
  Endocrine Pathology
• It's time to reconsider the newborn screening RUSP prospective pilot study "N of 1" rule.
  Molecular Genetics and Metabolism
• Follicular lymphoma B cells exhibit heterogeneous transcriptional states with associated somatic alterations and tumor microenvironments.
  Cell Reports
• Oncocytic poorly differentiated thyroid carcinoma.
  Mayo Clinic Proceedings
• The importance of estimating excess deaths regionally during the COVID-19 pandemic.
  Mayo Clinic Proceedings
• International reproducibility study of thymic epithelial tumors staging: pT stage is an issue. proposals for improvement. A RYTHMIC/ITMIG study.
  Lung Cancer
• COVID-19 infection and risk stratification for pulmonary embolism: Identifying optimal D-dimer thresholds.
  Thrombosis Research
• Pathologic-genomic correlation identified a novel variant in FN1 and established the diagnosis of recurrent fibronectin glomerulopathy in the kidney allograft.
  American Journal of Transplantation
• Synthesizing images of tau pathology from cross-modal neuroimaging using deep learning.
  Brain: A Neurology Journal
• "It's Pink!".
  Clinical Chemistry
• The role of artificial intelligence for providing scientific content for laboratory medicine.
  The Journal of Applied Laboratory Medicine
• Effect of residual platelets in frozen-thawed plasma on results of dilute Russell's viper venom time assay for lupus anticoagulant testing.
  American Journal of Clinical Pathology
• Serial high sensitivity troponin sampling in patients with SARS-CoV-2 infection.
  Clinical Biochemistry
• Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile.
  Clinical Biochemistry
• Pulmonary gangliocytic paraganglioma: An under-recognized mimic of carcinoid tumor.
  Human Pathology
• Oncocytic poorly differentiated thyroid carcinoma.
  Mayo Clinic Proceedings
• Guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2024 update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM).
  Clinical Infectious Diseases

Sarah Jarvis

Sarah Jarvis is a Senior Marketing Specialist at Mayo Clinic Laboratories. She supports marketing strategies for paid media.