Mayo Clinic Laboratories > Neurology > Autoimmune > Neuropathies > Ganglioside-associated neuropathies

Ganglioside-associated neuropathies

Clarifying challenging diagnoses

Identifying autoantibodies indicative of immune-mediated neuropathy can confirm the diagnosis and facilitate access to appropriate treatments for patients with neuropathy. Ganglioside antibody-associated neuropathy is a type of immune-mediated peripheral neuropathy that occurs when the immune system attacks gangliosides, which are glycosphingolipids found abundantly in the myelin linings of neural cells.

Because ganglioside antibodies are related to several serious but treatable disorders that can present similarly to more severe and even life-threatening conditions, identifying clinically relevant ganglioside antibodies can provide patients peace of mind and set them on the right path forward.

Ganglioside neuropathies Test menu

Ganglioside antibody evaluation

Ganglioside-associated neuropathies include Guillain-Barrè syndrome and its variants Miller Fisher syndrome, Bickerstaff brainstem encephalitis, multifocal motor neuropathy (MMN), and multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy. These conditions can be challenging to diagnose due to variable clinical presentations. Additionally, in certain instances, electromyography (EMG) test results may be normal early in the disease course.

Key testing

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