Autoimmune neurology

At the forefront of a testing evolution

Autoimmune neurology is a rapidly evolving subspecialty driven by the discovery that the immune system can target virtually any structure within the central and peripheral nervous systems. These conditions manifest as disorders previously thought to be independent and unrelated, and early and accurate diagnosis is paramount.

We are leading an evolution in autoimmune neurology diagnosis, with a phenotype-specific testing approach to effectively diagnose and guide treatment for these patients.


A history of innovation and discovery

The Mayo Clinic Neuroimmunology Laboratory was the first to introduce comprehensive serological evaluations for the diagnosis of paraneoplastic neurologic autoimmune disorders, a group of disorders in which unusual neurologic signs and symptoms are the initial manifestations of cancer.

The laboratory continues to discover and clinically validate novel autoantibody profiles that inform neurological decision-making and guide the search for cancer, leading an evolution in autoimmune neurology diagnosis. Powered by expertise from our research labs, clinical labs, and Autoimmune Neurology Clinic, we have developed panels customized to address specific phenotypes. This approach delivers more clinically actionable results, providing a clear picture of the diagnosis, prognosis, and treatment options.

“Clinicians are used to looking for patterns in their clinical work, and we’re transferring that expertise into a clinical laboratory space. That’s not something that you learn overnight — it’s gained with experience over years.”

Andrew McKeon, M.B., B.Ch., M.D.

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