Autoimmune pediatric disorders

An evaluation designed specifically for children

This first-of-its-kind profile includes only the antibodies that are pertinent to pediatric CNS disorders — all in one evaluation. The antibodies included are supported by clinical research, and the results of this testing can help with diagnosis and long-term treatment planning.


MOG antibody is 11 times more common
than AQP4 antibody in children

When to consider testing

Consider testing for children under 18 with suspected autoimmune encephalitis, or other autoimmune presentation such as ataxia or autoimmune encephalomyelitis, with one or more of the following:

  • Rapid onset and progression of symptoms over weeks to months
  • Behavioral changes such as unrelenting crying spells or tantrums — with or without clear cause — usually accompanied by one or more of the following: confusion, headaches, altered awareness, or movement disorder

Which test should I order?

Phenotypic evaluations

Our pediatric autoimmune evaluation is part of an evolving approach to testing for autoimmune neurological disorders using phenotypic-specific evaluations that include multiple antibodies known for their disease association.

A Test in Focus

Autoimmune encephalitis and myelitis is increasingly recognized as a cause of CNS disease in children and teens. Andrew McKeon, M.B., B.Ch., M.D., gives an overview of this test available through Mayo Clinic Laboratories. He discusses when this testing should be ordered, how this testing compares to other testing approaches, and what clinical action can be taken due to the results of this testing.

Learn more about how to order this evaluation at your institution.

Additional resources

Pediatric CNS Disorders

This “Specialty Testing” webinar addresses the clinical presentations, evaluation (including diagnostic antibody testing), and treatment of autoimmune pediatric CNS disorders, including encephalitides and myelopathies.