Mayo Clinic Laboratory and Pathology Research Roundup: March 27

By Kelley Luedke • March 27, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Pathogenic Implications of Distinct Patterns of Iron and Zinc in Chronic MS Lesions

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for iron and myelin, are the targets of injury. Metals are essential for normal CNS functioning, and metal imbalances have been linked to demyelination and neurodegeneration. Using a multidisciplinary approach involving synchrotron techniques, iron histochemistry and immunohistochemistry, Mayo Clinic researchers compared the distribution and quantification of iron and zinc in MS lesions to the surrounding normal appearing and periplaque white matter, and assessed the involvement of these metals in MS lesion pathogenesis. Researchers found that the distribution of iron and zinc is heterogeneous in MS plaques, and with few remarkable exceptions they do not accumulate in chronic MS lesions. They show that brain iron tends to decrease with increasing age and disease duration of MS patients; reactive astrocytes organized in large astrogliotic areas in a subset of smoldering and inactive plaques accumulate iron and safely store it in ferritin; a subset of smoldering lesions do not contain a rim of iron-loaded macrophages/microglia; and the iron content of shadow plaques varies with the stage of remyelination. Zinc in MS lesions was generally decreased, paralleling myelin loss. Iron accumulates concentrically in a subset of chronic inactive lesions suggesting that not all iron rims around MS lesions equate with smoldering plaques. Upon degeneration of iron-loaded microglia/macrophages, astrocytes may form an additional protective barrier that may prevent iron-induced oxidative damage. The study was published in Acta Neuropathologica.

Published to PubMed This Week

• Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function
  American Journal of Gastroenterology
• Open-Capsule Budesonide for Refractory Celiac Disease
  American Journal of Gastroenterology
  
• Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation
  Cell Reports
• Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay
  Clinical Chemistry
• Targeted Next Generation Sequencing and Identification of Risk Factors in World Health Organization Defined Atypical Chronic Myeloid Leukemia
  American Journal of Hematology
• Expression of PD-1 and PD-L1 in Anaplastic Thyroid Cancer Patients Treated with Multimodal Therapy: Results From a Retrospective Study
  Journal of Clinical Endocrinology & Metabolism
• Antibacterial and Biocompatible Titanium-Copper Oxide Coating May Be a Potential Strategy to Reduce Periprosthetic Infection: An In Vitro Study
  Clinical Orthopaedics and Related Research
• An Evaluation of Methods for Producing Low Titer Group O Whole Blood to Support Military Trauma Resuscitation
  Journal of Trauma and Acute Care Surgery
• Prehospital Blood Transfusion Programs: Capabilities and Lessons Learned
  Journal of Trauma and Acute Care Surgery
• Genetic Landscape and Classification of Peripheral T Cell Lymphomas
  Current Oncology Reports
• Iatrogenic Thyrotoxicosis and the Role of Therapeutic Plasma Exchange
  Journal of Clinical Apheresis
• Evaluation of the CLSI EP26-A Protocol for Detection of Reagent Lot-to-Lot Differences
  Clinical Biochemistry
• Complex p.T88N/W130R Mutation in the Lysozyme Gene Leading to Hereditary Lysozyme Amyloidosis with Biopsy-Proven Cardiac Involvement
  Amyloid
• Increased Risk of Large-for-Gestational Age Birthweight in Singleton Siblings Conceived with in Vitro Fertilization in Frozen Versus Fresh Cycles
  Journal of Assisted Reproduction and Genetics
• BAP1 and PBRM1 in Metastatic Clear Cell Renal Cell Carcinoma: Tumor Heterogeneity and Concordance with Paired Primary Tumor
  BMC Urology
• Continuous Glucose Monitor Interference With Commonly Prescribed Medications
  Journal of Diabetes Science and Technology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.