Mayo Clinic Laboratory and Pathology Research Roundup: April 24

By Kelley Luedke • April 24, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Are We Using the Best Tumor Size Cut-Points for Renal Cell Carcinoma Staging?

Mayo Clinic researchers conducted a study to compare the predictive ability for oncologic outcomes among current tumor size cut-points and clinically relevant alternatives in order to determine which are optimal. Patients who underwent radical or partial nephrectomy between 1970-2010 for renal cell carcinoma were identified. Associations between tumor size and progression-free survival and cancer-specific survival were evaluated using Kaplan-Meier analyses and Cox models. Predictive ability was assessed using c-indexes. There were 536 patients who progressed and 354 who died from renal cell carcinoma. For renal cell carcinoma tumors ≤3.0cm, 10-year progression-free survival and cancer-specific survival rates were 93-95% and 97-99%, respectively. For tumors >3.0-4.0cm, progression-free survival and cancer-specific survival began to decline, with further gradual declines with increasing tumor size. Based on the results, renal cell carcinoma tumors ≤3.0cm in size are associated with favorable outcomes. Thereafter, risks of progression and renal cell carcinoma-death increase gradually with tumor size, with no compelling biological reason to endorse a given cut-point over another. The study was published in Urology.

Published to PubMed This Week

• Retinoic Acid Receptor Alpha Drives Cell Cycle Progression and is Associated with Increased Sensitivity to Retinoids in T-Cell Lymphoma
  Oncotarget
• The 2016 Revised World Health Organization Definition of 'Myelodysplastic Syndrome with Isolated del(5q)'; Prognostic Implications of Single Versus Double Cytogenetic Abnormalities
  British Journal of Haematology
  
• Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer
  JAMA Oncology
• A Phase 2 Study of Vorinostat in Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma
  Oncotarget
• Identifying a Subset of Patients with DCIS Who Have a Low Likelihood of Residual Disease at Surgical Excision Following a Core Needle Biopsy
  Journal of Surgical Oncology
• Successful Pacemaker Lead Extraction Involving an Ossified Thrombus: A Case Report
  Journal of Arrhythmia
• Characterization of Fusion Genes in Common and Rare Epithelial Ovarian Cancer Histologic Subtypes
  Oncotarget
• Disclosing Agents for the Intraoperative Identification of Biofilms on Orthopedic Implants
  Journal of Arthroplasty

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.