Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 1

By Kelley Luedke • January 1, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Multifaceted Fanconi Anemia Signaling

In 1927, Guido Fanconi described a hereditary condition presenting panmyelopathy accompanied by short stature and hyperpigmentation, now better known as Fanconi anemia. With this discovery the genetic and molecular basis underlying Fanconi anemia has emerged as a field of great interest. Fanconi anemia signaling is crucial in the DNA damage response (DDR) to mediate the repair of damaged DNA. This has attracted a diverse range of investigators, especially those interested in aging and cancer. However, recent evidence suggests Fanconi anemia signaling also regulates functions outside the DDR, with implications for many other frontiers of research. Mayo Clinic researchers discuss the characteristics of Fanconi anemia functions and expand upon current perspectives regarding the genetics of Fanconi anemia, indicating that Fanconi anemia plays a role in a myriad of molecular and cellular processes. The study was published in Trends in Genetics.

Published to PubMed This Week

• • • Computer-Aided Nodule Assessment and Risk Yield (CANARY) May Facilitate Non-Invasive Prediction of EGFR Mutation Status in Lung Adenocarcinomas
      Scientific Reports
    • Challenges in Surgical Pathology of Adrenocortical Tumours
      Histopathology
    • A Subset of Well-Differentiated Hepatocellular Carcinomas are Arginase-1 Negative
      Human Pathology
    • Adenovirus Platform Enhances Transduction Efficiency of Human Mesenchymal Stem Cells: An Opportunity for Cellular Carriers of Targeted TRAIL-Based TR3 Biologics in Ovarian Cancer
      PLoS One
    • Sex-Specific 99th Percentiles Derived from the AACC Universal Sample Bank for the Roche Gen 5 cTnT assay: Comorbidities and Statistical Methods Influence Derivation of Reference Limits
      Clinical Biochemistry
    • The Epidemiology and Clinical Associations of Portal Vein Thrombosis in Hospitalized Patients With Cirrhosis: A Nationwide Analysis From the National Inpatient Sample
      Journal of Hospital Medicine
    • Cytotoxicity of Local Anesthetics in Mesenchymal Stem Cells
      American Journal of Physical Medicine & Rehabilitation

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.