Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 8

By Kelley Luedke • January 8, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

How Is Cardiac Troponin Released from Injured Myocardium?

Cardiac troponin I and cardiac troponin T are nowadays the criterion biomarkers for the laboratory diagnosis of acute myocardial infarction due to their very high sensitivities and specificities for myocardial injury. However, still many aspects of their degradation, tissue release, and elimination from the human circulation are incompletely understood. Myocardial injury may be caused by a variety of different mechanisms, for example, myocardial ischaemia, inflammatory and immunological processes, trauma, drugs and toxins, and myocardial necrosis is preceded by a substantial reversible prelethal phase. Recent experimental data in a pig model of myocardial ischaemia demonstrated cardiac troponin release into the circulation from apoptotic cardiomyocytes as an alternative explanation for clinical situations with increased cardiac troponin without any other evidence for myocardial necrosis. However, the comparably lower sensitivities of all currently available imaging modalities, including cardiac magnetic resonance imaging for the detection of particularly non-focal myocardial necrosis in patients, has to be considered for cardiac troponin test result interpretation in clinical settings without any other evidence for myocardial necrosis apart from increased cardiac troponin concentrations as well. The study was published in European Heart Journal.

Published to PubMed This Week

• • • Autoimmune Encephalitis Epidemiology and a comparison to Infectious Encephalitis
      Annals of Neurology
    • Global Glomerulosclerosis with Nephrotic Syndrome; The Clinical Importance of Age Adjustment
      Kidney International
    • Surveillance for and Discovery of Borrelia Species in US Patients Suspected of Tickborne Illness
      Clinical Infectious Diseases
    • Hydroxychloroquine-Mediated Cardiotoxicity With a False-Positive 99m Technetium-Labeled Pyrophosphate Scan for Transthyretin-Related Cardiac Amyloidosis
      Circulation: Cardiovascular Imaging
    • Histopathologic Findings in Lungs of Patients Treated with Extracorporeal Membrane Oxygenation
      Chest
    • Risk Factors for Arterial Versus Venous Thrombosis in Polycythemia Vera: A Single Center Experience in 587 Patients
      Blood Cancer Journal
    • JAK2 Exon 12 Mutated Polycythemia Vera: Mayo-Careggi MPN Alliance Study of 33 Consecutive Cases and Comparison with JAK2V617F Mutated Disease
      American Journal of Hematology
    • Rifampin Resistance in Staphylococcus Epidermidis: Molecular Characterization and Fitness Cost of rpoB Mutations
      International Journal of Antimicrobial Agents
    • Osteogenic Stimulation of Human Adipose-Derived Mesenchymal Stem Cells Using a Fungal Metabolite That Suppresses the Polycomb Group Protein EZH2
      Stem Cells Translational Medicine
    • Amphotericin-Impregnated Polymethylmethacrylate Beads as Treatment for Soft Tissue Mucormycosis
      Surgery
    • Nomogram Prediction of Overall Survival for Patients with Non-Small-Cell Lung Cancer Incorporating Pretreatment Peripheral Blood Markers
      European Journal of Cardio-Thoracic Surgery
    • Cold Platelets for Trauma-Associated Bleeding: Regulatory Approval, Accreditation Approval, and Practice Implementation-Just the "Tip of the Iceberg"
      Transfusion
    • How Do I … Manage the Platelet Transfusion-Refractory Patient?
      Transfusion
    • STAT3 Mutation and Its Clinical and Histopathologic Correlation in T-Cell Large Granular Lymphocytic Leukemia
      Human Pathology
    • A Comprehensive Analysis of Breast Cancer Microbiota and Host Gene Expression
      PLoS One
    • Calcium Channel Autoimmunity: Cerebellar Ataxia and Lambert-Eaton Syndrome Coexisting
      Muscle Nerve
    • Composite Ganglioside Autoantibodies and Immune Treatment Response in MMN and MADSAM
      Muscle Nerve
    • Giant Cell Ependymoma of Lateral Ventricle: Case Report, Literature Review, and Analysis of Prognostic Factors and Genetic Profile
      World Neurosurgery
    • Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome
      World Neurosurgery
    • Intracranial Metastasis in Fibrolamellar Hepatocellular Carcinoma
      Pediatric Blood & Cancer
    • Computer-Aided Diagnosis of Contrast-Enhanced Spectral Mammography: A Feasibility Study
      European Journal of Radiology
    • Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome
      Journal of Neurogastroenterology and Motility
    • Registered Nurse Intent to Promote Physical Activity for Hospitalized Liver Transplant Recipients
      Journal of Nursing Management
    • Alternative Outpatient Chemotherapy Scheduling Method to Improve Patient Service Quality and Nurse Satisfaction
      Journal of Oncology Practice
    • Cytotoxicity of Local Anesthetics in Mesenchymal Stem Cells
      American Journal of Physical Medicine & Rehabilitation

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.