Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 10

By Kelley Luedke • December 10, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

The Evaluation of Monoclonal Gammopathy of Renal Significance: A Consensus Report of the International Kidney and Monoclonal Gammopathy Research Group

The term monoclonal gammopathy of renal significance (MGRS) was introduced by the International Kidney and Monoclonal Gammopathy Research Group (IKMG) in 2012. The IKMG met in April 2017 to refine the definition of MGRS and to update the diagnostic criteria for MGRS-related diseases. Accordingly, in this Expert Consensus Document, the IKMG redefines MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined haematological criteria for treatment of a specific malignancy. The diagnosis of MGRS-related disease is established by kidney biopsy and immunofluorescence studies to identify the monotypic immunoglobulin deposits (although these deposits are minimal in patients with either C3 glomerulopathy or thrombotic microangiopathy). Accordingly, the IKMG recommends a kidney biopsy in patients suspected of having MGRS to maximize the chance of correct diagnosis. Serum and urine protein electrophoresis and immunofixation, as well as analyses of serum free light chains, should also be performed to identify the monoclonal immunoglobulin, which helps to establish the diagnosis of MGRS and might also be useful for assessing responses to treatment. Finally, bone marrow aspiration and biopsy should be conducted to identify the lymphoproliferative clone. Flow cytometry can be helpful in identifying small clones. Additional genetic tests and fluorescent in situ hybridization studies are helpful for clonal identification and for generating treatment recommendations. The study was published in Nature Reviews: Nephrology.

Published to PubMed This Week

• • • • • Pancreatic Tumor Cell Metastasis Is Restricted by MT1-MMP Binding Protein MTCBP-1
          Journal of Cell Biology
        • 20+ Years and Alive with Primary Myelofibrosis: Phenotypic Signature of Very Long-Lived Patients
          American Journal of Hematology
        • The Germline JAK2 GGCC (46/1) Haplotype and Survival Among 414 Molecularly Annotated Patients with Primary Myelofibrosis
          American Journal of Hematology
        • Role of Systemic High-Dose Methotrexate and Combined Approaches in the Management of Vitreoretinal Lymphoma: A Single Center Experience 1990–2018
          American Journal of Hematology
        • A Data Science Approach for the Classification of Low-Grade and High-Grade Ovarian Serous Carcinomas
          BMC Genomics
        • Identification of Adenosquamous Carcinoma as a Rare Aggressive HER2-negative Subgroup of Esophageal/Gastroesophageal Junction Adenocarcinoma
          American Journal of Clinical Oncology
        • High-Grade Squamous Cell Carcinoma Arising in a Tibial Adamantinoma
          Human Pathology
        • Clinical Use of Cardiac Troponin for Acute Cardiac Care and Emerging Opportunities in the Outpatient Setting
          Minerva Medica
        • Rapid Rule-Out of Suspected Acute Coronary Syndrome in the Emergency Department by High-Sensitivity Cardiac Troponin T Levels at Presentation
          Internal and Emergency Medicine
        • Constitutional Chromosome Rearrangements That Mimic the 2017 World Health Organization "Acute Myeloid Leukemia with Recurrent Genetic Abnormalities": A Study of Three Cases and Review of the Literature
          Cancer Genetics
        • Risk Factors for Subsequent Urethral Atrophy in Patients Undergoing Artificial Urinary Sphincter Placement
          Turkish Journal of Urology
        • Association of Mitochondrial DNA Copy Number with Self-Rated Health Status
          The Application of Clinical Genetics

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.