Mayo Clinic Laboratory and Pathology Research Roundup: April 22
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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Type 2 Myocardial Infarction: JACC Review Topic of the Week
Acute myocardial infarction (MI) can occur from increased myocardial oxygen demand and/or reduced supply in the absence of acute atherothrombotic plaque disruption, a condition called type 2 myocardial infarction (T2MI). As with any MI subtype, there must be clinical evidence of myocardial ischemia to make the diagnosis. This condition is increasingly diagnosed due to the increasing sensitivity of cardiac troponin assays and is associated with adverse short-term and long-term prognoses. Limited data exist defining optimal management strategies because T2MI is a heterogeneous entity with varying etiologies and triggers. Thus, these patients require individualized care. A major barrier is the absence of a uniform definition that can be operationalized with high reproducibility. This document provides a synthesis of the data about T2MI to assist clinicians' understanding of its pathobiology, when to deploy the diagnosis, and its associated treatments. It also clarifies prognosis, identifies gaps in knowledge, and provides recommendations for moving forward.
Published to PubMed This Week
- Acute Noncardiac Organ Failure in Acute Myocardial Infarction with Cardiogenic Shock
Journal of the American College of Cardiology - Angiosarcoma of the Liver: Clinicopathologic Features and Morphologic Patterns
The American Journal of Surgical Pathology - X-Linked Lymphoproliferative Syndrome Presenting as Adult-Onset Multi-Infarct Dementia
Journal of Neuropathology and Experimental Neurology - Whole Genome Sequencing Reveals Complexity in Both HPV Sequences Present and HPV Integrations in HPV-Positive Oropharyngeal Squamous Cell Carcinomas
BMC Cancer - Increased Incidence of Cutaneous Keratinocytic and Melanocytic Malignancies in Patients with Age-Related Macular Degeneration
Retina - Use of FFPE-Derived DNA in Next-Generation Sequencing: DNA Extraction Methods
PLoS One - Solid Pseudopapillary Neoplasms of the Pancreas: A Large American Cohort
Pancreas - Localization of Liver Lesions in Abdominal CT Imaging: I. Correlation of Human Observer Performance between Anatomical and Uniform Backgrounds
Physics in Medicine and Biology - Altered Physical Performance Following Advanced Special Operations Tactical Training
Journal of Strength and Conditioning Research - Updates in Spindle Cell/Pleomorphic Lipomas
Seminars in Diagnostic Pathology - Single Antibody Detection of T-Cell Receptor αβ Clonality by Flow Cytometry Rapidly Identifies Mature T-Cell Neoplasms and Monotypic Small CD8-Positive Subsets of Uncertain Significance
Cytometry. Part B, Clinical Cytometry - Low Ureaplasma Polymerase Chain Reaction Positivity Rate among Newborns in a Neonatal Intensive Care Unit or Intermediate Special Care Nursery
The Pediatric Infectious Disease Journal - Cutaneous Lesions of Angioimmunoblastic T-cell Lymphoma: Clinical, Pathological, and Immunophenotypic Features
Journal of Cutaneous Pathology - Tubal Remnant with Rectosigmoid Stricture in the Background of Endometriosis
Journal of Minimally Invasive Gynecology - Same-Day Discharge Following Vaginal Hysterectomy with Pelvic Floor Reconstruction: a Pilot Study
Journal of Minimally Invasive Gynecology
