Mayo Clinic Laboratory and Pathology Research Roundup: May 28

By Alyssa Frank • May 28, 2019

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Molecular Subtyping of Clinically Localized Urothelial Carcinoma Reveals Lower Rates of Pathological Upstaging at Radical Cystectomy Among Luminal Tumors

Determining whether bladder cancer has spread beyond the bladder is challenging at diagnosis. In this paper, genomics helped identify patients who were more likely to have aggressive disease that has spread outside the bladder. These patients may benefit from chemotherapy prior to surgery. Molecular subtyping of clinically localized UC demonstrated that luminal tumors have lower rates of upstaging to non-organ-confined disease compared with nonluminal tumors. If validated, these data can help inform which patients may need multimodal therapy.

Published to PubMed This Week

• Targeting Glycogen Synthase Kinase 3 for Therapeutic Benefit in Lymphoma
  Blood
• Recurrent MSC ^E116K Mutations in ALK-Negative Anaplastic Large Cell Lymphoma
  Blood
• Proteasome Inhibition Boosts Autophagic Degradation of Ubiquitinated-AGR2 and Enhances the Antitumor Efficiency of Bevacizumab
  Oncogene
• Using Genomics to Differentiate Multiple Primaries from Metastatic Lung Cancer
  Journal of Thoracic Oncology
• Revision Total Hip Arthroplasty for the Treatment of Fracture: More Expensive, More Complications, Same Diagnosis-Related Groups: A Local and National Cohort Study
  Journal of Bone and Joint Surgery
• Polyclonal Serum Free Light Chain Elevation is Associated with Increased Risk of Monoclonal Gammopathies
  Blood Cancer Journal
• Early Results of a Phase I Trial Using an Adipose-Derived Mesenchymal Stem Cell-Coated Fistula Plug for the Treatment of Transsphincteric Cryptoglandular Fistulas
  Diseases of the Colon and Rectum
• Implications of Bacteriophage- and Bacteriophage Component-Based Therapies For The Clinical Microbiology Laboratory
  Journal of Clinical Microbiology
• Albumin In Situ Hybridization Can Be Positive in Adenocarcinomas and Other Tumors From Diverse Sites
  American Journal of Clinical Pathology
• Lack of Correlation of Virulence Gene Profiles of Staphylococcus Aureus Bacteremia Isolates with Mortality
  Microbial Pathogenesis
• ANNALS EXPRESS: Gadolinium-Based Contrast Agents: A Clinically Significant Analytical Interference in ICP-MS Elemental Analysis
  Annals of Clinical Biochemistry
• Improved Interpretability of Machine Learning Model Using Unsupervised Clustering: Predicting Time to First Treatment in Chronic Lymphocytic Leukemia
  JCO Clinical Cancer Informatics
• Diagnostic Value of Imprint Cytology Testing in Kidney Tumors: Review of 200 Cases
  Journal of the American Society of Cytopathology
  

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.