Mayo Clinic Laboratory and Pathology Research Roundup: July 22

By Samantha Rossi • July 22, 2019

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.

Pancreatic cystic lesions (PCLs) may be precancerous. Those likely to harbor high-grade dysplasia (HGD) or pancreatic cancer (PC) are targets for surgical resection. Current algorithms to predict advanced neoplasia (HGD/PC) in PCLs lack diagnostic accuracy. In pancreatic tissue and cyst fluid (CF) from PCLs, we sought to identify and validate novel methylated DNA markers (MDMs) that discriminate HGD/PC from low-grade dysplasia (LGD) or no dysplasia (ND).

Published to PubMed This Week

• Integration of Machine Learning and Mechanistic Models Accurately Predicts Variation in Cell Density of Glioblastoma Using Multiparametric MRI.
  Scientific Reports
• OLIG2 Is a Marker of the Fusion Protein-Driven Neurodevelopmental Transcriptional Signature in Alveolar Rhabdomyosarcoma.
  Human Pathology
• Incidence of Succinate Dehydrogenase and Fumarate Hydratase-Deficient Renal Cell Carcinoma Based on Immunohistochemical Screening with SDHA/SDHB and FH/2SC.
  Human Pathology
• What Are We REALLY Looking for in a Letter of Recommendation?
  Journal of Surgical Education
• Phosphaturic Mesenchymal Tumors: A Review and Update.
  Seminars in Diagnostic Pathology
• Assessment of The Bethesda System for Reporting Thyroid Cytopathology.
  American Journal of Clinical Pathology
• Immunohistochemical and Ultrastructural Features of Hepatocellular Cytoplasmic Globules in Venous Outflow Impairment.
  American Journal of Clinical Pathology
• A Fatal Case of Disseminated Microsporidiosis Due to Anncaliia algerae in a Renal and Pancreas Allograft Recipient.
  Open Forum Infectious Disease

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.