Mayo Clinic Laboratory and Pathology Research Roundup: March 2

By Samantha Rossi • March 2, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer from a Clinical Genetic Testing Cohort.

A total of 54,555 invasive breast cancer patients with 56,480 breast tumors were subjected to clinical hereditary cancer multigene panel testing. Heterogeneity for predisposition genes across clinical breast cancer subtypes was assessed by comparing mutation frequencies by gene among tumor subtypes and by association studies between each tumor subtype and reference controls. Via Journal of National Cancer Institute.

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Published to PubMed This Week

• The Critical Role of Psychosine in Screening, Diagnosis, and Monitoring of Krabbe Disease.
  Genetic Medicine
• Anastrozole has an Association Between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α.
  Clinical Cancer Research
• Emergence of a Novel Coronavirus Disease (COVID-19) and the Importance of Diagnostic Testing: Why Partnership between Clinical Laboratories, Public Health Agencies, and Industry Is Essential to Control the Outbreak.
  Clinical Chemistry
• Blood Mass Spectrometry Detects Residual Disease Better than Standard Techniques in Light-Chain Amyloidosis.
  Blood Cancer Journal
• Systematic Use of Fluorescence in situ Hybridization (FISH) and Clinicopathological Features in the Screening of PDGFRB Rearrangements of Patients with Myeloid/Lymphoid Neoplasms.
  Histopathology
• Correction to: Update on Lymphoproliferative Disorders of the Gastrointestinal Tract: Disease Spectrum from Indolent Lymphoproliferations to Aggressive Lymphomas.
  Virchows Archiv
• Review of Treatment Modalities and Outcomes of Patients with Basal Cell Adenocarcinoma.
  American Journal of Otolaryngology
• Topical Vancomycin for Treatment of Methicillin-Resistant Staphylococcus Epidermidis Infection in a Rat Spinal Implant Model.
  Spine Deformity
• Mass Cytometry Identifies Expansion of Double Positive and Exhausted T Cell Subsets in the Tumour Microenvironment of Patients with POEMS Syndrome.
  British Journal of Haematology
• The Role of Extracellular Vesicles and PD-L1 in Glioblastoma-Mediated Immunosuppressive Monocyte Induction.
  Neuro Oncology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.