Mayo Clinic Laboratory and Pathology Research Roundup: March 9

By Samantha Rossi • March 9, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Utilizing Multiparametric Flow Cytometry in the Diagnosis of Patients with Primary Plasma Cell Leukemia.

The diagnosis of primary plasma cell leukemia (pPCL) has been made by quantifying circulating plasma cells (cPCs) morphologically on a peripheral blood (PB) smear. However, this technique is not sufficiently sensitive. Multiparametric flow cytometry (MFC) provides a readily available and highly sensitive method to identify and quantify cPCs that could complement PB smear assessment. However, an optimal quantitative cutoff for cPCs by MFC to identify pPCL has not been established. Thus, a total of 591 patients newly diagnosed multiple myeloma (NDMM) patients who had their PB samples evaluated morphologically by PB smear and immunophenotypically by MFC prior to beginning therapy were evaluated. The presence of >200 cPCs/microliter (μL) by MFC (N = 25 or 5% of the total population) was chosen to identify patients with >5% cPCs by PB smear with a specificity of 99% and a sensitivity of 77%. For patients with >200 cPCs/μL by MFC compared to the remainder of the cohort, the median TTNT was 18 vs. 30 months and the median OS was 38 vs. 70 months respectively. Thus, MFC assessment of PB can be utilized in conjunction with the morphological assessment of a PB smear to aid in improving the identification of pPCL among NDMM patients. This article is protected by copyright. All rights reserved. Via American Journal of Hematology.

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Published to PubMed This Week

• Evaluation of Germline Genetic Testing Criteria in a Hospital-Based Series of Women With Breast Cancer.
  Journal of Clinical Oncology
• Association of tumor genomic factors and efficacy for metastasis-directed stereotactic body radiotherapy for oligometastatic colorectal cancer.
  Radiotherapy Oncology
• Outcomes and patient perspectives following implementation of tiered opioid prescription guidelines in gynecologic surgery.
  Gynecology Oncology
• "Double-hit" of DUSP22 and TP63 rearrangements in anaplastic large cell lymphoma, ALK-negative.
  Blood
• Electromagnetic Guided Percutaneous Renal Access Outcomes Among Surgeons and Trainees of Different Experience Levels: A Pilot Study.
  Urology
• Characteristics Associated With Recruitment and Re-contact in Mayo Clinic Biobank.
  Front Public Health
• Response to erythropoiesis-stimulating agents in patients with WHO-defined myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T).
  British Journal of Haematology
• The professional sabbatical: A systematic review and considerations for the health-system pharmacist.
  Research in Social and Administrative Pharmacy

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.