Mayo Clinic Laboratory and Pathology Research Roundup: October 12

By Samantha Rossi • October 12, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Implications of MYC Rearrangements in Newly Diagnosed Multiple Myeloma.

A rearrangement involving MYC was found in 8% of patients and was associated with elevated β2-microglobulin, ≥50% bone marrow plasma cells, IgA multiple myeloma, and the cooccurrence of trisomies. There were no differences in overall response rates between patients with and without MYC rearrangement when induction chemotherapy was proteasome inhibitor (PI)-based, immunomodulatory drug (IMiD)-based or PI + IMiD-based. Overall survival was shorter in patients with MYC rearrangement compared with patients without MYC rearrangement (5.3 vs. 8.0 years, P < 0.001). MYC rearrangement was associated with increased risk of death on multivariate analysis when high-risk cytogenetic abnormalities, ISS stage III, and ≥70 years of age were included (risk ratio: 1.5; P = 0.007). Via Clinical Cancer Research.

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Published to PubMed This Week

• Utility of Repeating Bone Marrow Biopsy for Confirmation of Complete Response in Multiple Myeloma.
  Blood Cancer Journal
• In Reply-Repeated Testing in SARS-CoV-2 Infection.
  Mayo Clinic Proceedings
• High-Grade Serous Carcinoma of the Fallopian Tube.
  Mayo Clinic Proceedings
• Diagnostic Stewardship: An Essential Element in a Rapidly Evolving COVID-19 Pandemic.
  Mayo Clinic Proceedings
• Brain Ischemic Injury in COVID19 Infected Patients: A Series of 10 Post-Mortem Cases.
  Brain Pathology
• Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3 in ANCA-Associated Vasculitis.
  Frontiers in Immunology
• Application, Verification and Implementation of SARS-CoV-2 Serologic Assays with Emergency Use Authorization.
  Journal of Clinical Microbiology
• Quantitative Assessment of Portal Hypertension with Bi-Parametric Dual-Frequency Hepatic MR Elastography in Mouse Models.
  European Radiology
• The Novel Form of Amyloidosis Derived From EGF-Containing Fibulin-Like Extracellular Matrix Protein 1 (EFEMP1) Preferentially Affects the Lower Gastrointestinal Tract of Elderly Females.
  Histopathology
• Clinical Predictors and Timing of Cessation of Viral RNA Shedding in Patients with COVID-19.
  Journal of Clinical Virology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.