Mayo Clinic laboratory and pathology research roundup: May 18

By Samantha Rossi • May 18, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome.

Richter syndrome (RS) refers to transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma. RS is known to be associated with a number of genetic alterations such as TP53 and NOTCH1 mutations. Via Blood Cancer Journal.

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Published to PubMed This Week

• Prevalence of SARS-CoV-2 antibodies in a multistate academic medical center.
  Mayo Clinic Proceedings
• Angiosarcoma of the adrenal gland.
  Mayo Clinic Proceedings
• Striking association of lymphoid enhancing factor (LEF1) overexpression and DUSP22 rearrangements in anaplastic large cell lymphoma.
  American Journal of Surgical Pathology
• Pathology of fibropolycystic liver diseases.
  Clinical Liver Disease
• Activity of biodegradable polymeric nanosponges against dual-species bacterial biofilms.
  ACS Biomater Science Engineering
• Optic chiasm involvement in AQP-4 antibody-positive NMO and MOG antibody-associated disorder.
  Multiple Sclerosis
• Markers of bile acid metabolism in pediatric diarrhea predominant irritable bowel syndrome and healthy controls.
  Journal of Pediatric Gastroenterology and Nutrition
• Low-grade oncocytic tumor of kidney (CK7-Positive, CD117-Negative): Incidence in a single institutional experience with clinicopathological and molecular characteristics.
  Human Pathology
• SATB2 is expressed in a subset of pulmonary and thymic neuroendocrine tumors.
  American Journal of Clinical Pathology
• Pathologic spectrum and molecular landscape of myeloid disorders harboring SF3B1 mutations.
  American Journal of Clinical Pathology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.