Mayo Clinic Laboratory and pathology research roundup: October 5
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Therapeutic trials in adult FSGS: lessons learned and the road forward.
Focal segmental glomerulosclerosis (FSGS) is not a specific disease entity but a lesion that primarily targets the podocyte. In a broad sense, the causes of the lesion can be divided into those triggered by a presumed circulating permeability factor, those that occur secondary to a process that might originate outside the kidneys, those caused by a genetic mutation in a podocyte or glomerular basement membrane protein, and those that arise through an as yet unidentifiable process, seemingly unrelated to a circulating permeability factor. A careful attempt to correctly stratify patients with FSGS based on their clinical presentation and pathological findings on kidney biopsy is essential for sound treatment decisions in individual patients. However, it is also essential for the rational design of therapeutic trials in FSGS. Greater recognition of the pathophysiology underlying podocyte stress and damage in FSGS will increase the likelihood that the cause of an FSGS lesion is properly identified and enable stratification of patients in future interventional trials. Such efforts will facilitate the identification of effective therapeutic agents. Via PubMed
Published to PubMed This Week
- Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities.
Alzheimer's and Dementia - APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia.
Science Translational Medicine - Lenalidomide in combination with R-CHOP produces high response rates and progression-free survival in new, untreated diffuse large B-cell lymphoma transformed from follicular lymphoma: results from the Phase 2 MC078E study.
Blood Cancer Journal - Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases.
Kidney International - A mutation in the SAA1 promoter causes hereditary amyloid A amyloidosis.
Kidney International - Venetoclax for the treatment of multiple myeloma: Outcomes outside of clinical trials.
American Journal Hematology - Isolated T-cell acute lymphoblastic leukemic optic disc infiltration.
American Journal Hematology - Accuracy of a rapid multiplex PCR plus a chromogenic phenotypic test algorithm for detection of ESBL and carbapenemase-producing Gram-negative bacilli in positive blood culture bottles.
Clinical Infectious Disease - Genetic profiling and biomarkers in peripheral T-cell lymphomas: current role in the diagnostic work-up.
Modern Pathology - The Elevated High-Sensitivity Cardiac Troponin T Pilot: Diagnoses and Outcomes.
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