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A simpler path to answers for patients with mast cell activation syndrome

A random urine test panel aids in diagnosing mast cell activation syndrome (MCAS), a complex condition often misdiagnosed due to overlapping symptoms. The panel improves access, speeds up diagnosis, and enables individualized treatment by detecting key mast cell mediators.

August 11, 2025
Rabbits, Chikungunya, and More Viral News: Matthew Binnicker, Ph.D.
August 28, 2025

In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, and Matthew Binnicker, Ph.D., a microbiologist and virologist and chief scientific officer of Mayo Clinic Laboratories, discuss recent developments in viral infections.

Elevating Clinical Lab Websites in a Changing Technology Landscape
August 25, 2025

In this episode of the “Leveraging the Laboratory” podcast, host Jane Hermansen, outreach manager at Mayo Clinic Laboratories, is joined by Travis Engelhaupt, digital experience director, and Naomi Lovell, project manager. Together, they discuss website trends and best practices.

Practical Legal Insight and Tips: Compliance Issues for Hospital Laboratory Outreach Programs
August 20, 2025

Register now – Nov. 19, 2025: Regulatory compliance and recent policy changes at the federal and state levels relevant to hospital laboratory outreach programs.

Never Let the Fear of Needles Keep You from Saving Lives
March 10, 2017

Benjamin Tetlie, a Financial Representative for Mayo Clinic Global Business Solutions, used to have a strong aversion to the idea of donating blood. However, when his coworkers organized a Blood Donor Unit Challenge, he wanted to participate.

Staffing to Workload: Indirect Effort
March 2, 2017

Mike Baisch, Systems Engineer at Mayo Clinic, discusses the mechanics of performing a staffing-to-workload analysis in the testing laboratories. There are three primary areas of focus with staffing needs: direct effort, indirect effort, and operational needs. This post focuses on indirect effort.

Patient Satisfaction in the Nursery [Pediatric Phlebotomy]
February 15, 2017

This "Pediatric Phlebotomy" presentation addresses the increase in the number of tests available using a blood spot specimen and concerns about bruising, a team was created to investigate causes of bruising and select the best method for collecting blood from infants.

Staffing to Workload: Direct Effort
January 26, 2017

Mike Baisch, Systems Engineer at Mayo Clinic, discusses the mechanics of performing a staffing-to-workload analysis in the testing laboratories. There are three primary areas of focus with staffing needs: direct effort, indirect effort, and operational needs. This post focuses on direct effort.

Communiqué
Beyond the Test Result: Greg Widseth
December 20, 2016

Greg Widseth was suddenly hit by a rare disease that prompted his immune system to attack his brain cells, resulting in as many as 60 seizures a day. Special blood and spinal fluid tests developed by Mayo Medical Laboratories confirmed that Widseth had antibodies known to target certain brain cells.

Understanding Membranoproliferative Glomerulonephritis, Including C3 Glomerulopathy: Part 2
July 6, 2016

Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated MPGN. In this “Hot Topic,” Senjeev Sethi, M.D., Ph.D., demonstrates the use of the new classification with case studies.

Understanding Membranoproliferative Glomerulonephritis, Including C3 Glomerulopathy: Part 1
July 6, 2016

Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated MPGN. In this “Hot Topic,” Senjeev Sethi, M.D., Ph.D., demonstrates the use of the new classification with case studies.

Lyme Disease, Part 2: <em>Borrelia mayonii</em>–A New Cause of Lyme Disease in Upper Midwest
May 16, 2016

In this “Hot Topic,” Bobbi Pritt, M.D., discusses how Lyme disease is the most common vector-borne illness in the United States and Europe and caused primarily by Borrelia burgdorferi in the United States, while B burgdorferi, B afzelii, and B garinii cause Lyme disease in Europe. We will also discuss using PCR and melting curve analysis to identify a new species of Borrelia.

Lyme Disease Part 1: The Common Culprits Worldwide–<em>Borrelia burgdorferi, Borrelia garinii, Borrelia afzelii</em>
May 2, 2016

In this “Hot Topic,” Elitza Theel, Ph.D., discusses how common cases of presumed Lyme disease go unreported each year and discusses scenarios in which testing for Lyme disease is indicated and reviews both recommended and inappropriate testing methodologies. The overall focus is on performance of the CDC endorsed two-tiered serologic testing algorithm and the latest CDC recommendations.

Should You Worry if You Accidentally Swallow an Insect?
July 27, 2015

During summer activities, it's bound to happen. But how dangerous is it to accidentally swallow a bug? Bobbi Pritt, M.D., a microbiologist, pathologist, and Director of the Clinical Parasitology Laboratory at Mayo Clinic in Rochester, discusses when swallowing an insect is harmless and which ones can be dangerous in The Wall Street Journal column entitled, "Burning Question."

Myeloproliferative Neoplasm: Morphology, Molecular Updates and Cost-Effective Test Utilization
July 15, 2015

The diagnosis of Myeloproliferative Neoplasm (MPN) must include an integrated approach and combine the clinical findings with laboratory results. In our latest “Hot Topic,” Rong He, M.D., discusses the subclassification of MPNs and the use of JAK2, CALR, and MPL mutational analysis in diagnosis and prognosis.

Myeloid Blast and Maturation Assessment by Flow Cytometry (“MDS Flow”)
July 1, 2015

Flow cytometric immunophenotyping method can be useful in assessing myeloid dysmaturation. In this “Hot Topic,” Dragon Jevremovic, M.D., Ph.D., describes a new flow cytometric test to detect aberrant patterns of expression in the diagnosis of myelodysplastic syndrome.

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