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A Mayo Pathologist’s Journey through Paraneoplastic Syndrome and a Double Lung Transplant: Dr. Brad Karon

After mysterious neurological symptoms began in 2010, Brad Karon, M.D., Ph.D., was diagnosed with paraneoplastic syndrome, a rare condition that led to groundbreaking research and test development at Mayo Clinic. Years later, pulmonary fibrosis and a double lung transplant would test him once again — and redefine his resilience.

July 21, 2025
A simpler path to answers for patients with mast cell activation syndrome
August 11, 2025

A random urine test panel aids in diagnosing mast cell activation syndrome (MCAS), a complex condition often misdiagnosed due to overlapping symptoms. The panel improves access, speeds up diagnosis, and enables individualized treatment by detecting key mast cell mediators.

Keynote speakers set for 2025 Classical Hematology Conference
August 6, 2025

At this year's Classical Hematology Conference we will be joined by Hematology experts, Adam Cuker, M.D. and Stephan Moll, M.D. Reserve your spot today.

Dr. Bill Morice offers data-driven reasons to retain lab services
August 5, 2025

William Morice II, M.D., Ph.D., highlights data-driven reasons health systems benefit from the lab service line and strategies to bolster performance.

New tests launched in July
August 4, 2022

In July 2022, Mayo Clinic Laboratories announced fifteen new tests along with numerous reference value changes, obsolete tests, and algorithm changes.

Operationalizing monkeypox testing: John Osborn
August 4, 2022

John Osborn, operations administrator in the Department of Laboratory Medicine and Pathology at Mayo Clinic, joins the "Answers From the Lab" podcast for a discussion with host Bobbi Pritt, M.D. about monkeypox testing. In this episode, John and Dr. Pritt discuss how Mayo Clinic swiftly operationalized monkeypox testing and the challenges involved with supporting the new assay, including staffing.

Mayo Clinic Labs @Work: Todd Walker
August 3, 2022

Todd Walker is a laboratory supervisor for Mayo Clinic Laboratories, Specimen Operations, where he helps lead the department that serves as the gateway between collecting and delivering specimens and getting them processed. Todd credits his diverse, agile team and the impressive global logistics infrastructure that allows them to support the processing of 40,000 specimens in a day.

Nonradioactive assay helps diagnose heparin reaction
August 2, 2022

Rajiv Pruthi, M.B.B.S., explains how Mayo Clinic Laboratories’ serotonin release assay achieves high sensitivity and specificity while avoiding the use of radioactive materials. Serotonin release testing is an important tool in the diagnosis of heparin induced thrombocytopenia, or HIT, which can have devastating consequences for patients.

Mayo Clinic Laboratory and pathology research roundup: August 2
August 2, 2022

This week's research roundup features: Gastrointestinal stromal tumors mimicking gynecologic disease: clinicopathological analysis of 20 cases.

CPT codes and LOINC update: July 2022
August 2, 2022

This page includes updates posted to mayocliniclabs.com during the month of July.

Heparin Induced Thrombocytopenia (HIT) and the Role of Serotonin Release Assay (SRA)
August 1, 2022

In this month's "Hot Topic," Rajiv Pruthi, M.B.B.S., discusses heparin induced thrombocytopenia (HIT), approach diagnosis, and the role of the functional serotonin release assay (SRA).

Week in Review: July 29
July 29, 2022

Topic highlights include: Mayo Clinic in Rochester again ranked country's top hospital: U.S. news and world report, WHO declares monkeypox a global health emergency as infections soar, Depression is likely not caused by a chemical imbalance in the brain, study says.

William Morice, II, M.D., Ph.D., shares potential impacts of the VALID Act
July 29, 2022

William Morice II, M.D., Ph.D., president of Mayo Clinic Laboratories, shares his concerns about the VALID Act, which if passed would give the FDA oversight of laboratory-developed tests. VALID could hamper labs’ test development activity, increase costs for labs, and disproportionately affect smaller labs or those with fewer resources. It could also lead to more test development partnerships and lab collaboration.

Monkeypox declared a global public health emergency: Dr. Bill Morice
July 28, 2022

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins "Answers From the Lab" for his weekly leadership update with podcast host Bobbi Pritt, M.D. In this episode, Dr. Pritt and Dr. Morice discuss the World Health Organization’s declaration of monkeypox as a global public health emergency, how Mayo Clinic Laboratories quickly implemented testing, and the public-private partnership to manage the response.

FDA-approved test expands options for Alzheimer’s disease
July 26, 2022

Joshua Bornhorst, Ph.D., describes the new, FDA-approved Alzheimer's disease (AD) test and how it differs from Mayo Clinic Laboratories' existing AD evaluation. The laboratory will offer both tests, to ensure flexibility and options for managing clinical care.

Mayo Clinic Laboratory and pathology research roundup: July 26
July 26, 2022

This week's research roundup features: Motor-neuron-disease-like phenotype associated with IgLON5 disease.

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