As health care organizations continue to respond to COVID-19, Mayo Clinic Laboratories remains in full service for your reference laboratory needs. We offer a comprehensive menu of COVID-19 and related testing.


Molecular Testing

Recommended only for patients who meet current clinical and/or epidemiologic criteria defined by federal, state, or local public health directives.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA Detection, Varies (Test ID: COVID)

Useful for detection of COVID-19 due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)


Serology Testing

Note: COVID-19 testing is currently available only to clients who have received prior approval. For more information, contact Customer Service at 800-533-1710.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) IgG Antibody, Serum (Test ID: VCOV2)

Useful for detection of IgG-class antibodies against SARS-CoV-2, the virus that causes COVID-19.


COVID-19 Related Testing

Note: As discussed in a recent Mayo Clinic Proceedings article, there is still no high-quality evidence to support many proposed drug therapies. We encourage the enrollment of eligible patients to multiple ongoing clinical trials that assess the efficacy and safety of these candidate therapies. Until the results of controlled trials are available, none of the suggested therapeutics is clinically proven as an effective therapy for COVID-19.

However, as research and clinical experience continue to evolve around management of COVID-19 patients, clinicians may find use in the following laboratory tests:

Interleukin 6, Plasma (Test ID: IL6)

Severe COVID-19 patients are characterized by a higher baseline IL-6 level compared to non-severe infections. In critically ill patients with COVID-19, IL-6 levels were almost tenfold higher. While it is not clear whether elevation in IL-6 has a causal association with pro-inflammatory damage of the lungs or is just a consequence of the lung infection, attempts at blocking IL-6 by using monoclonal antibodies directed against IL-6 receptors have garnered interested as a potential therapeutic option

Hydroxychloroquine, Serum (Test ID: HCQ)

Hydroxychloroquine (HCQ) is an antimalarial drug that is currently FDA-approved for systemic lupus erythematosus (SLE), malaria, and rheumatoid arthritis. In laboratory tests, hydroxychloroquine can prevent the SARS-CoV and SARS-CoV-2 viruses from attaching to and entering cells. If these antiviral abilities work the same way in animals and humans, the drug could be used to treat patients and limit the number of COVID-19 deaths. Dosage recommendations vary based on clinical indications, and the long terminal elimination half-life of HCQ should be considered. Accumulation of HCQ occurs in multiple organs and can result in mild to severe toxicity. Therapeutic drug monitoring (TDM) can be used as an objective measure to effectively manage patients prescribed HCQ

Glucose-6-Phosphate Dehydrogenase (G-6-PD), Quantitative, Erythrocytes (TEST ID: G6PD)

In addition to the risk of toxicity from HCQ, hemolysis has been reported in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency during the post-approval use of hydroxychloroquine sulfate tablets, USP. While patients receiving HCQ do not routinely need G6PD levels checked before initiating therapy, testing should be considered in patients who are of Mediterranean, African, or Asian descent

Quantitative Lymphocyte Subsets: T, B, and Natural Killer (NK), Blood (Test ID: TBBS)

One of the most characteristic changes in COVID-19 patients is lymphopenia. In addition to total lymphocytes, T cells (CD4+ T cells, CD8+ T cells), B cells, and natural killer (NK) cells are all decreased in COVID-19 patients compared to healthy controls. These cell counts correlate with severity and also normalize in post-treatment patients who recover. For severe cases of COVID-19, further analysis may be required and experts in Mayo Clinic’s Cellular and Molecular Immunology Laboratory are available for further discussion.