Mayo Clinic Laboratories > Hematology > Lymphoid neoplasms > B-cell and T-cell acute lymphoblastic leukemia

B-cell and T-cell acute lymphoblastic leukemia

Individualized test options

In the United States, the incidence of acute lymphoblastic leukemia (ALL) is approximately 1 in 50,000. Acute lymphoblastic leukemia accounts for approximately 70% of all childhood leukemia cases (ages 0 to 19 years), making it the most common type of childhood cancer. It has a peak incidence at 2–5 years of age. The incidence decreases with increasing age, before increasing again at around age 50. 

Our fluorescence in situ hybridization (FISH) testing is designed to simplify the ordering process by providing diagnostic panels that include all appropriate genes.

B-cell and T-cell acute lymphoblastic leukemia Test menu

B-cell and T-cell acute lymphoblastic leukemia

A combination of cytogenetic and FISH testing is currently recommended in all pediatric and adult patients to characterize the B-ALL and T-ALL clones for the prognostic genetic subgroups. Each of the genetic subgroups is important to detect, can be critical prognostic markers, and can assist in treatment selection. 

A newly recognized World Health Organization (WHO) entity BCR-ABL1-like ALL, also known as Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL), is increasing in importance due to the poor prognosis seen in pediatric, adolescent, and young adult ALL. Common features of this entity involve rearrangements with tyrosine kinase genes involving the following: ABL2, PDGFRB, JAK2, ABL1, CRLF2, P2RY8, and deletions involving IKZF1. Patients who have failed conventional therapies have demonstrated favorable responses to targeted therapies when rearrangements involving these specific gene regions have been identified.

Key testing



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