B-cell lymphoma

Testing to aid in diagnosis

Mature B-cell lymphoma can be low grade, intermediate grade, or high grade, and the prognosis and clinical course are highly variable. Genetic abnormalities have emerged as one of the most important prognostic markers in B-cell lymphomas and can aid in diagnosis. Several chromosome abnormalities and variants of these abnormalities have been associated with various lymphoma subtypes. FISH testing allows for the detection of abnormal genes associated with various chromosome translocations and inversions in B-cell lymphoma.

The following FISH probes available at Mayo Clinic are associated with specific B-cell lymphoma subtypes, including:

Comprehensive testing simplified

Our approach to fluorescence in situ hybridization (FISH)testing is designed to simplify the ordering process by providing diagnostic panels that include all appropriate genes.

Which test should I order?

BLPMF | B-cell Lymphoma, Specified FISH

  • Probe set(s) performed are based on concurrent flow cytometry results (if available), reason for referral, or what is specified upon ordering

BLYM | B-Cell Lymphoma, FISH, Tissue

  • Detecting a neoplastic clone associated with the common chromosome abnormalities seen in patients with various B-cell lymphomas

PATHC | Pathology Consultation

  • In addition to an extensive IHC and thoughtfully crafted FISH testing, Mayo Clinic’s hematopathology team has extensive experience with T-cell neoplasms and frequently provides consultations for clients around the globe

High Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements with Diffuse Large B-Cell Lymphoma Morphology

High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) is a newly defined entity in the latest World Health Organization Classification.

Learn more about how to order these evaluations at your institution.