B-cell lymphoma

Testing to aid in diagnosis

Mature B-cell lymphoma can be low grade, intermediate grade, or high grade, and the prognosis and clinical course are highly variable. Genetic abnormalities have emerged as one of the most important prognostic markers in B-cell lymphomas and can aid in diagnosis. Several chromosome abnormalities and variants of these abnormalities have been associated with various lymphoma subtypes (see table below). FISH testing allows for the detection of abnormal genes associated with various chromosome translocations and inversions in B-cell lymphoma.

The following FISH probes available at Mayo Clinic are associated with specific B-cell lymphoma subtypes, including:

In addition to an extensive IHC and thoughtfully crafted FISH testing, Mayo Clinic’s hematopathology team has extensive experience with T-cell neoplasms and frequently provides consultations for clients around the globe.

High Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements with Diffuse Large B-Cell Lymphoma Morphology

High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) is a newly defined entity in the latest World Health Organization Classification.

Which test should I order?

Learn more about how to order these evaluations at your institution.