Eosinophilia

Advanced analysis for rare disease

Lymphoid/myeloid neoplasms with eosinophilia are a group of rare, significantly diverse hematologic malignancies characterized by rearrangements of the PDGFRA, PDGFRB, FGFR1, JAK2, or ABL1 genes that result in the formation of fusion transcripts and abnormal tyrosine kinase activity. Despite varying clinical presentations, the diagnostic subgroup shares rearrangements involving four specific gene regions.1

Eosinophilia Test menu

Eosinophilia

Patients with the condition can present with myeloproliferative neoplasm, myelodysplastic syndrome, and de novo or secondary mixed phenotype leukemias. While eosinophilia often accompanies the illness, it is not always present.2

Key testing


References
  1. Spitzer B, et al. ETV6-FLT3–positive myeloid/lymphoid neoplasm with eosinophilia presenting in an infant: an entity distinct from JMML. Blood Adv. 2021:5(7):1899-1902. doi:https://doi.org/10.1182/bloodadvances.2020003699
  2. Reiter A, Gotlib J. Myeloid neoplasms with eosinophilia. Blood. 2017 Feb 9;129(6):704-714. doi:10.1182/blood-2016-10-695973. Epub 2016 Dec 27. PMID: 28028030.
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