Lymphoid neoplasm with eosinophilia

Advanced analysis for rare disease

Lymphoid/myeloid neoplasms with eosinophilia are a group of rare, significantly diverse hematologic malignancies characterized by rearrangements of the PDGFRA, PDGFRB, FGFR1, JAK2, or ABL1 genes that result in the formation of fusion transcripts and abnormal tyrosine kinase activity. Despite varying clinical presentations, the diagnostic subgroup shares rearrangements involving four specific gene regions.1

Patients with the condition can present with myeloproliferative neoplasm, myelodysplastic syndrome, as well as de novo or secondary mixed phenotype leukemias. While eosinophilia often accompanies the illness, it is not always present.2

Comprehensive testing simplified

Our approach to fluorescence in situ hybridization (FISH)testing is designed to simplify the ordering process by providing diagnostic panels that include all appropriate genes.

Key testing

EOSDF | Chronic Eosinophilia, Diagnostic, FISH

  • When ordered, entire EOS FISH panel will be performed

EOSMF | Chronic Eosinophilia, Specified, FISH

  • Probe set(s) to be performed must be specified upon ordering. Any probe set captured under EOSDF can be ordered

Learn more about how to order these evaluations at your institution.


  1. Spitzer B, et al. ETV6-FLT3–positive myeloid/lymphoid neoplasm with eosinophilia presenting in an infant: an entity distinct from JMML. Blood Adv 2021: 5(7):1899-1902. doi:
  2. Reiter A, Gotlib J. Myeloid neoplasms with eosinophilia. Blood. 2017 Feb 9;129(6):704-714. doi: 10.1182/blood-2016-10-695973. Epub 2016 Dec 27. PMID: 28028030.