Advanced analysis for rare disease

Lymphoid/myeloid neoplasms with eosinophilia are a group of rare, significantly diverse hematologic malignancies characterized by rearrangements of the PDGFRA, PDGFRB, FGFR1, JAK2, or ABL1 genes that result in the formation of fusion transcripts and abnormal tyrosine kinase activity. Despite varying clinical presentations, the diagnostic subgroup shares rearrangements involving four specific gene regions.¹

Patients with the condition can present with myeloproliferative neoplasm, myelodysplastic syndrome, as well as de novo or secondary mixed phenotype leukemias. While eosinophilia often accompanies the illness, it is not always present.²

Comprehensive testing simplified

Our approach to fluorescence in situ hybridization (FISH)testing is designed to simplify the ordering process by providing diagnostic panels that include all appropriate genes.

EOSDF | Chronic Eosinophilia, Diagnostic, FISH

• When ordered, entire EOS FISH panel will be performed

EOSMF | Chronic Eosinophilia, Specified, FISH

• Probe set(s) to be performed must be specified upon ordering. Any probe set captured under EOSDF can be ordered