Acute myeloid leukemia

Results with clinical significance

The presence and pattern of gene mutations in a known or suspected hematologic neoplasm can provide critical diagnostic, prognostic, and therapeutic information for physicians. While many hematologic neoplasms show morphologic or phenotypic similarities, most harbor a distinct composition of somatic gene mutations. Many myeloid neoplasms lack a clonal bone marrow cytogenetic finding at diagnosis (normal karyotype) but can be better characterized with the aid of a comprehensive gene mutation profile.

Clinically validated testing

We strive to provide the highest quality molecular services available to complement your clinical practice by offering a robust menu of clinically validated testing, including:

  • Genetic testing panels, including MayoComplete next-generation sequencing: a comprehensive, 47-gene myeloid neoplasms oncoheme panel and two acute myeloid leukemia (AML)-focused subpanels.
  • A comprehensive, disease-specific menu of fluorescence in situ hybridization (FISH) panels.
  • Molecular analysis that combines reverse transcription, real-time polymerase chain reaction (RT-PCR) technology, and DNA-based fragment analysis to evaluate measurable residual disease (MRD).
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