Maintaining a diverse and sufficient blood supply is essential for hospital care, as transfusions support many critical treatments. Several known red blood cell antigens make donor-recipient matching complex, especially across diverse populations, highlighting the need to overcome barriers such as mistrust or lack of awareness in underrepresented communities. In the U.S., blood donors must meet specific health and eligibility requirements to ensure safety for both donor and recipient. The following podcast episodes feature blood banking-related interviews that discuss these topics.