Patients with axonal autoimmune neuropathy have variable sensory and motor disturbance and can present with symptoms that result from injury to the distal nerves, roots, ganglia, or their gathering points. Patients may have symmetric or asymmetric involvements of the extremities, trunk, and head including extraocular muscles. Subacute onset and asymmetric involvements more commonly indicate inflammatory or immune causes rather than inherited or metabolic forms. Other parts of the nervous system may also be affected based on the specific inflammatory or immune-mediated causes.
Because of the overlap of clinical symptoms, we recommend a panel-based approach rather than individual antibody testing.
Axonal autoimmune neuropathies Test menu
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Anastasia Zekeridou, M.D., Ph.D., explains how Mayo Clinic Laboratories' updated panels and methodology boost the accuracy and efficiency of testing for three autoimmune neurology biomarkers. Early diagnosis is key to managing debilitating conditions associated with these antibodies.
Div Dubey, M.B.B.S., explains Mayo Clinic Laboratories' phenotypic testing approach for autoimmune axonal neuropathy. The comprehensive, serologic panel detects for antibodies with clinical relevance to the disease to provide clarity on etiology, prognosis, and treatment choices.