Chronic inflammatory demyelinating polyradiculoneuropathy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare, oftentimes severe immune-mediated neurological disorder involving peripheral nerve and nerve root inflammation leading to destruction of the protective myelin sheath covering nerve fibers. Frequently misdiagnosed, CIDP in most cases is highly responsive to first-line immunotherapy treatments, such as intravenous immunoglobin (IVIG). However, a subset of individuals with specific paranodal antibodies do not respond as well to these therapies.
Among patients affected by CIDP, the presence of neurofascin 155 (NF155) IgG4 and contactin-1 (CNTN1) IgG indicates a unique disease etiology with antibodies targeting the paranode. These patients have relatively poor treatment response to IVIG. Mayo Clinic Laboratories has developed and validated a unique approach to test for these antibodies. This assay combination is available exclusively at Mayo Clinic Laboratories.
While most CIDP patients present similarly, certain disease associations can help differentiate between disease variants.
A Test in Focus
Divyanshu (Div) Dubey, M.B.B.S., describes Mayo Clinic Laboratories' new diagnostic test for CIDP, or chronic inflammatory demyelinating polyneuropathy. The new test detects two antibodies — NF155 and CNTN1 — to enhance diagnosis and guide treatment decisions. Often misdiagnosed, CIDP is treatable if detected early.
Learn more about how to order this evaluation at your institution.
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