Demyelinating disease
Similar characteristics. Different treatments.
The clinical and radiologic features of neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein (MOG-IgG) associated disease (MOGAD), and MS are similar. However, the appropriate treatments for MOGAD and NMOSD are significantly different than for MS.
- MS is treated by immunomodulation therapy, which may worsen NMOSD.
- NMOSD and MOGAD are treated by immunosuppressant therapy.
An accurate diagnosis of these diseases is critical for physicians and their patients.
“The value of better testing is translated into better answers from the lab to providers and to patients, and to all clients of the laboratory.”
Maria Alice Willrich, Ph.D., co-director, Antibody Immunology, Protein Immunology, and Clinical Mass Spectrometry laboratories
News and updates
The latest
PACE/State of FL - This webinar will discuss the advantages of using electrophysiology results to guide the selection of axonal or demyelinating testing for peripheral neuropathy. This approach can help identify specific antibodies associated with the condition, providing a more precise diagnosis, and improving patient outcomes. Accurate diagnosis is crucial for effective treatment, as the therapeutic approach varies based on the underlying cause of peripheral neuropathy.
John Mills, Ph.D., and Divyanshu Dubey, M.B.B.S., explain how Mayo Clinic Laboratories' new test panel can distinguish among various potential causes of demyelinating neuropathies. Test results are important for managing these devastating autoimmune conditions.
Anastasia Zekeridou, M.D., Ph.D., explains how Mayo Clinic Laboratories' updated panels and methodology boost the accuracy and efficiency of testing for three autoimmune neurology biomarkers. Early diagnosis is key to managing debilitating conditions associated with these antibodies.
Divyanshu Dubey, M.B.B.S., explains how Mayo Clinic Laboratories' unique PDE10A and TRIM46 tests facilitate the management of central nervous system disorders triggered by cancers. Early diagnosis and treatment are important for managing disabling neurological symptoms and malignancy.
Tying together the expertise and curiosity of Mayo Clinic autoimmune neurology researchers with eager patients who have rare disease and are looking for answers, the innovative collaboration benefits both patients affected by MOGAD and scientists on the front lines of discovery.
Joe Mondloch and his wife Sue have existed in a grey area of uncertainty due to the unpredictable autoimmune neurological illness Joe has lived with for the last seven years. Rare, incurable, and debilitating, the newly classified disorder can be hard to manage. But thanks to information and direction provided by a rare disease advocacy group, the Mondlochs sought care at Mayo Clinic and received much more than answers.
In this month's "Hot Topic," Eoin Flanagan, M.B., B.Ch., reviews the recent diagnostic criteria for Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD).
Mayo Clinic researchers have identified clear differences in brain and spinal cord scarring in patients with demyelinating diseases.
Maria Alice Willrich, Ph.D., explains kappa free light chain testing — Mayo Clinic Laboratories' data-driven approach to diagnose multiple sclerosis. The automated assay is more sensitive, cost-effective, and faster than traditional oligoclonal banding, enabling definitive answers for the challenging diagnosis.
Lying in an ICU bed as sick as he could get, Jon Bratsch thought he was past the point of no return. But when a Mayo Clinic Laboratories’ test revealed the source of his dire symptoms, everything changed. Today, Jon’s back to the life and family he loves.
John Mills, Ph.D., explains Mayo Clinic Laboratories’ approach to MAG antibody testing. The ELISA-based assay uses higher reference ranges and human MAG antigen to detect MAG antibodies, which are associated with a rare, hard-to-treat condition known as DADS neuropathy.
In this month’s “Hot Topic,” Andrew McKeon, M.B., B.Ch., M.D., reviews the use of neurological phenotype-based evaluations, the move away from the paraneoplastic evaluation, and upcoming changes to test profiles.
The clinical, radiologic, and serologic characteristics of autoimmune myelopathies and their mimics.