Referred Tests
Distinguishing autoimmune demyelinating diseases
from MS
The importance of an
accurate diagnosis
Identifying antibodies that are contributing factors in CNS demyelinating diseases allows physicians to provide a clear diagnosis for patients and implement an appropriate treatment regimen designed to reduce the risk of relapse.
Neuromyelitis optica
spectrum disorders
Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system. NMO is characterized by severe relapsing attacks of optic neuritis and transverse myelitis. Unlike the attacks associated with multiple sclerosis (MS), NMO attacks commonly spare the brain in the early stages.
The spectrum of NMO was traditionally restricted to the optic nerves and the spinal cord. In 2004, Mayo Clinic scientist Vanda Lennon, M.D., Ph.D., reported an antibody that targets aquaporin-4 (AQP4), the water channel on astrocytes, and it is a sensitive and specific biomarker for NMO. Since that discovery, a much broader category called “NMO spectrum disorders” (NMOSD) has evolved.
Myelin oligodendrocyte glycoprotein (MOG)-opathy
Detection of MOG-IgG is diagnostic of central nervous system (CNS) inflammatory demyelination, where the clinical phenotype (NMO, optic neuritis, transverse myelitis, acute disseminated encephalomyelitis [ADEM]) may be similar, but the immunopathology (astrocytopathy vs. oligodendrogliopathy) and clinical outcome (worse vs. better) are different. Detection of MOG-IgG also predicts disease relapse.
More importantly, MOG-IgG seropositive inflammatory demyelinating diseases (IDDs) are distinct from MS and are treated differently, and these MS treatments have been reported to worsen MOG-IgG seropositive IDDs.
By the numbers
32%
Recurrent optic neuritis patients
who are positive for AQP4-IgG or MOG-IgG
1/3
of AQP4-IgG (-) NMO patients are positive for MOG-IgG
1.5x
frequency that MOG-IgG is positive compared to AQP4-IgG
Ensuring better patient outcomes
Due to significant overlap in the clinical phenotypes, we recommend testing AQP4 and MOG-IgGs at the same time. This synchronized testing method allows for a faster diagnosis and treatment plan decision for your patient.
Similar characteristics, different treatment
- While NMOSD and MOG-opathies are treated by immunosuppressant therapy, MS is treated by immunomodulatory therapy, which may worsen NMOSD.
- For patients who are AQP4-IgG positive, optimal immunosuppressive therapy should be initiated as soon as possible (a negative result in a subject where NMOSD is suspected should receive follow-up in 3 to 6 months).
- For patients who are MOG-IgG positive, immunosuppressive therapy may be justified as soon as possible; follow-up in 6 to 12 months is recommended, as persistence of MOG-IgG seropositivity predicts a relapsing course.
Early diagnosis
is critical
- Initiating therapy early in the course to eliminate recurrence of attacks will minimize patient disability.
- If not treated appropriately, within five years, 50% of NMO patients lose functional vision in at least one eye or are unable to walk. Recent data suggests that patients with MOG-opathy may have less disability.
FACS: A superior method of testing
Mayo Clinic has developed the only fluorescence activated cell sorting (FACS) live cell-binding assay that is currently available in the U.S. for antibody detection of AQP4 and MOG. FACS is recommended by international leaders in neuroimmunology for its increased sensitivity and specificity.
Learn more about how to order this evaluation at your institution.
Which test should I order?
Additional resources
In this month’s “Hot Topic,” Sean Pittock, M.D., explains Neuromyelitis Optica Spectrum Disorder (NMOSD) and the critical importance of a sensitive and specific AQP4-IgG laboratory test for early diagnosis and treatment.
Antibodies to aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) are recently described biomarkers seen in a subset of atypical optic neuritis which have revolutionized our understanding of the condition. In this “Hot Topic,” my colleague, Dr. John Chen, will review these advances and how they impact the clinical care of our patients with optic neuritis.
"This study offers hope to patients, since each attack in NMO can cause loss of visual or motor function," says Sean Pittock, M.D., a Mayo Clinic neurologist and first author.
This "Specialty Testing" webinar will provide an overview of novel biomarker discoveries and advances being made in the study of autoimmune gliopathies.