Hereditary
Efficient, optimized answers
Some children may present with clinical features suspicious of an inherited cancer syndrome or may inherit certain genetic mutations from a parent that increase their risk for developing cancer. For these young patients, testing to identify genetic variations can help providers better understand the risk of inherited cancer predisposition.1
Inherited pediatric cancers test menu
Hereditary
Our pediatric hereditary cancer test offerings include single-gene assays that evaluate specific genes already identified in a parent with a hereditary cancer syndrome. Our highly trained genetic counselors can work with providers to personalize testing for more than one familial variant, if indicated.
Key testing
- NF1Z | Neurofibromatosis Type 1, NF1, Full Gene Analysis, Varies
- Facilitates diagnosis in patients with a personal or family history suggestive of neurofibromatosis type 1 (NF1).
- Allows for targeted cancer surveillance based on associated risks.
- Identifies genetic variants associated with increased risk for NF1, allowing for predictive testing of at-risk family members.
- PTNZ | PTEN Hamartoma Tumor Syndrome, PTEN Full Gene Analysis, Varies
- Facilitates diagnosis in patients with a personal or family history suggestive of PTEN hamartoma tumor syndrome (PHTS).
- Allows for targeted cancer surveillance based on associated risks.
- Identifies variants within genes known to be associated with increased risk for PHTS, allowing for predictive testing of at-risk family members.
- RETZZ | Multiple Endocrine Neoplasia Type 2 Syndrome, RET, Full Gene Analysis, Varies
- Facilitates diagnosis in patients with a personal or family history suggestive of a multiple endocrine neoplasia type 2 (MEN2) or Hirschsprung disease (HSCR).
- Allows for targeted cancer surveillance based on associated risks.
- Identifies variants within genes known to be associated with MEN2 or HSCR, allowing for predictive testing of at-risk family members.
- VHLZZ | Von Hippel Lindau Syndrome, VHL, Full Gene Analysis, Varies
- Facilitates diagnosis in patients with a personal or family history suggestive of Von Hippel-Lindau (VHL) syndrome.
- Allows for targeted cancer surveillance based on associated risks.
- Identifies genetic variants associated with increased risk for VHL syndrome, allowing for predictive testing of at-risk family members.
References
- Screening for cancer in children. Finding cancer in children. American Cancer Society. https://www.cancer.org/cancer/cancer-in-children/finding-childhood-cancers-early.html, Revised Oct 14, 2019. Accessed Feb. 9, 2023.