Initiate treatment earlier
The leading cause of pulmonary renal syndrome
Pulmonary renal syndrome (PRS) is characterized by rapidly progressive glomerulonephritis (RPGN) and diffuse alveolar hemorrhage secondary to an autoimmune response. The most common causes of PRS in adults are ANCA-associated vasculitis (AAV) and anti-GBM disease. Due to the overlap in clinical presentation, frequency of RPGN, and the need for early diagnosis and treatment, testing for ANCA and anti-GBM is recommended during the differential diagnosis.
Improve outcomes through comprehensive testing
Prompt identification of ANCA and anti-GBM antibodies allows for early initiation of treatment and may improve patient outcomes. Antibodies to GBM antigens cause glomerulonephritis, Goodpasture’s syndrome, and, less commonly, pulmonary hemosiderosis. Anti-neutrophil cytoplasmic antibodies occur in various types of autoimmune diseases including renal limited vasculitis (e.g., Wegener’s granulomatosis [WG] or microscopic polyangiitis [MPA]) and pauci-immune necrotizing GN.1 Comprehensive testing, prompt result reporting, and access to more than 150 years of advanced medical knowledge deliver the answers your practice needs to keep care local.
Update on the management of ANCA-associated vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis comprises three different syndromes — granulomatosis with polyangiitis (GPA, also known as Wegener's granulomatosis); microscopic polyangiitis (MPA); and eosinophilic granulomatosis with polyangiitis (EGPA, also known as Churg-Strauss syndrome) — all with frequent respiratory manifestations.
Establish the diagnosis
Identifies GBM antibodies to aid in diagnosing anti-GBM disease or Goodpasture’s syndrome.
Confirm disease subtype
Distinguish Wegener’s granulomatosis from microscopic polyangiitis by identifying the presence of antineutrophil cytoplasmic antibodies.