| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
Membranous nephropathy (MN) is one of the leading causes of nephrotic syndrome in adults. It is traditionally classified into primary and secondary membranous nephropathy. Cases without associated disorders are termed primary membranous nephropathy (PMN) while cases associated with other conditions, such as different autoimmune diseases, infectious or parasitic diseases, tumor, or adverse reactions to certain medications, are referred to as secondary membranous nephropathy (SMN).
As more antigens that autoantibodies recognize are identified, the distinction between PMN and SMN is becoming blurred. While certain target antigens are more strongly associated with specific secondary causes,1 other autoantibodies associated with the same antigen can be associated with both types. The variable and unpredictable natural course of MN and other associated diseases results in ongoing challenges for disease management.2
70%
70% of patients with primary MN are positive for PLA2R
2%-5%
2%–5% of patients with primary MN are positive for NELL-1
1%
1% of patients with primary MN are positive for THSD7A
Membranous nePHropathy test menu
Mayo Clinic Laboratories offers a comprehensive menu of clinically validated assays to assist with the diagnosis of PMN, monitor disease progression, and guide clinical outcomes.
Key testing
Advantages
Highlights
John Lieske, M.D., describes Mayo Clinic Laboratories' new test for primary membranous nephropathy. PMND1 is a diagnostic cascade that provides a cost-effective approach to detecting antigens known to cause membranous nephropathy — a condition that can lead to kidney failure.
Mayo Clinic Laboratories offers a comprehensive menu of ancillary renal pathology tests to assist with the diagnosis of membranous nephropathy.
Highlights
Mayo Clinic renal pathologist Dr. Sanjeev Sethi identified NELL-1 as a biomarker for membranous nephropathy (MN) in 2019. Two years later, Dr. Sethi helped implement the first ever IHC test to detect NELL-1 antigen, which appears in about 10% of MN patients and is linked to underlying malignancy.
Sanjeev Sethi, M.D., Ph.D., discusses how Mayo Clinic Laboratories’ new immunohistochemistry test for the detection of NELL-1 antigen, a biomarker for membranous nephropathy found in 10% to 15% of patients, provides diagnostic certainty and insight on disease expression.