Membranous nephropathy (MN) is one of the leading causes of nephrotic syndrome in adults. It is traditionally classified into primary and secondary membranous nephropathy. Cases without associated disorders are termed primary membranous nephropathy (PMN) while cases associated with other conditions, such as different autoimmune diseases, infectious or parasitic diseases, tumor, or adverse reactions to certain medications, are referred to as secondary membranous nephropathy (SMN).
As more antigens that autoantibodies recognize are identified, the distinction between PMN and SMN is becoming blurred. While certain target antigens are more strongly associated with specific secondary causes,1 other autoantibodies associated with the same antigen can be associated with both types. The variable and unpredictable natural course of MN and other associated diseases results in ongoing challenges for disease management.2
70% of patients with primary MN are positive for PLA2R
2%–5% of patients with primary MN are positive for NELL-1
1% of patients with primary MN are positive for THSD7A
Membranous nePHropathy test menu
Mayo Clinic Laboratories offers a comprehensive menu of clinically validated assays to assist with the diagnosis of PMN, monitor disease progression, and guide clinical outcomes.
Mayo Clinic Laboratories offers a comprehensive menu of ancillary renal pathology tests to assist with the diagnosis of membranous nephropathy.
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