Therapeutics testing: A clear path to accurate answers
"The goal is not to identify every drug technically possible, but to perform medically necessary testing for those drugs that are most likely to impact clinical outcomes.”

The benefits of Mayo Clinic Laboratories therapeutics testing
Empowering confidence through unmatched clinical expertise
A team of nationally recognized laboratory leaders, who are fully integrated with the clinical practice at Mayo Clinic, develops and validates our testing. These experts are available for consultative support and provide interpretive result reporting, which reinforces the clinical relevance of our testing.
Cost-effective, evidence-based testing
Our data-supported, algorithmic approach optimizes clinical outcomes by directing laboratory leaders and healthcare professionals to medically necessary testing for each patient. This approach increases the value of our testing and supports appropriate test utilization without sacrificing patient care.
Comprehensive, cutting-edge menu
Featuring more than 200 tests across the therapeutics testing spectrum, the depth and breadth of our menu is unparalleled. Our menu continues to evolve as ongoing research initiatives drive continuous testing improvements.
Propelling testing excellence through education
The involvement of our laboratory physicians and scientists in Mayo Clinic-led research and their active participation in guidelines development allows for unparalleled clinical alignment and a data-driven innovation pipeline that powers the testing of the future.
Our digital resource demonstrates how our full-spectrum therapeutics testing can be applied throughout the patient journey. Encompassing test use cases for controlled substance monitoring, PGx testing, and TDM, our informative guide provides insider insights on the role of therapeutics testing in providing superior outcomes.

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Fill out the form to download our digital guide to therapeutics testing at Mayo Clinic Laboratories. Therapeutics testing: Delivering impactful clinical outcomes through smart, compliant testing
Highlights
Jessica Wright, Pharm.D., BCACP, explains how Mayo Clinic Laboratories' 3A5Q test helps determine initial tacrolimus doses for individuals after non-liver organ transplants. Optimal tacrolimus levels are one of the important factors in survival of the transplanted organ.
PACE/State of FL - Substance use disorders and the common laboratory tests and matrices used for controlled substance monitoring.
Ann Moyer, M.D., Ph.D., explains how Mayo Clinic Laboratories' unique genetic tests identify patients at high risk of severe reactions to fluoropyrimidines — a type of chemotherapy drug. Test results can guide clinical decision-making for safer cancer treatment.
Bringing together advanced testing technology, unparalleled expertise, and a patient-focused approach, Mayo Clinic Laboratories’ new high-resolution urine drug testing profile, ADMPU, evaluates for 22 drug classes including alcohol, marijuana, and nicotine, enabling clarity on substance use and precision insights that propel treatment.
Controlled substance testing options vary in the details they provide about patient drug use, painting an incomplete picture of usage patterns that can hinder accurate prescription monitoring and treatment outcomes. However, a new comprehensive Controlled Substance Monitoring Panel, developed by the Clinical and Forensic Toxicology Laboratory at Mayo Clinic Laboratories, offers in-depth analysis on more than 70 different prescription medications and illicit substances to provide clinicians with details and interpretations on patients’ controlled substance use lacking in other laboratory assays.
Seamless integration, quality assurance, operational support
Each of Mayo Clinic Laboratories’ testing laboratories is fully CLIA-certified and CAP-accredited, and we participate in U.S. and international proficiency programs. Our ordering systems are compatible with major laboratory information systems and electronic medical records, allowing for seamless ordering and reporting.
A streamlined, end-to-end laboratory solution
From clarifying which substances a patient is taking to understanding how one’s genes impact treatment efficacy to monitoring therapy, Mayo Clinic Laboratories delivers a comprehensive menu designed to support labs in providing high-impact results. View our full menu of therapeutics testing.

Highlights
Reviewing the challenges healthcare providers face in distinguishing between new and residual marijuana use in patients.
Paul Jannetto, Ph.D., explains the advantages that Mayo Clinic Laboratories' oral fluid drug screening offers over typical urine tests. Oral samples are easier to collect and harder to adulterate.
Tobacco use is the leading cause of preventable death in the United States. In this test-specific episode of the "Answers From the Lab" podcast, Paul Jannetto, Ph.D., explains how Mayo Clinic Laboratories' nicotine testing benefits patients in smoking cessation programs and other settings.
Recognizing the powerful role genes can play in diagnosing illness and guiding treatment, the Division of Laboratory Genetics and Genomics at Mayo Clinic spearheaded a testing expansion, implementing and upgrading more than 60 advanced sequencing and biochemical assays in 2023 and planning for even more this year.